Technical challenges of working with extracellular vesicles

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dc.citation.issue3
dc.citation.volume10
dc.contributor.authorRamirez, Marcel Ivan
dc.contributor.authorAmorim, Maria G.
dc.contributor.authorGadelha, Catarina
dc.contributor.authorMilic, Ivana
dc.contributor.authorWelsh, Joshua A.
dc.contributor.authorFreitas, Vanessa Morais
dc.contributor.authorNawaz, Muhammad
dc.contributor.authorAkbar, Naveed
dc.contributor.authorCouch, Yvonne
dc.contributor.authorMakin, Laura
dc.contributor.authorCooke, Fiona
dc.contributor.authorVettore, Andre Luiz [UNIFESP]
dc.contributor.authorXander, Patricia [UNIFESP]
dc.contributor.authorFreezor, Roberta
dc.contributor.authorPezuk, Julia A.
dc.contributor.authorRosa-Fernandes, Livia
dc.contributor.authorCarreira, Ana Claudia Oliveira
dc.contributor.authorDevitt, Andrew
dc.contributor.authorJacobs, Laura
dc.contributor.authorSilva, Israel T.
dc.contributor.authorCoakley, Gillian
dc.contributor.authorNunes, Diana Noronha
dc.contributor.authorCarter, Dave
dc.contributor.authorPalmisano, Giuseppe
dc.contributor.authorDias-Neto, Emmanuel
dc.coverageCambridge
dc.date.accessioned2020-07-08T13:09:52Z
dc.date.available2020-07-08T13:09:52Z
dc.date.issued2018
dc.description.abstractExtracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with potential applications in diagnosis, prognosis and therapeutic guidance in most pathological conditions. These nano-sized particles transmit signals determined by their protein, lipid, nucleic acid and sugar content, and the unique molecular pattern of EVs dictates the type of signal to be transmitted to recipient cells. However, their small sizes and the limited quantities that can usually be obtained from patient-derived samples pose a number of challenges to their isolation, study and characterization. These challenges and some possible options to overcome them are discussed in this review.en
dc.description.affiliationFundacao Oswaldo Cruz, Rio De Janeiro, RJ, Brazil
dc.description.affiliationUniv Fed Parana, Curitiba, Parana, Brazil
dc.description.affiliationAC Camargo Canc Ctr, CIPE, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Nottingham, Sch Life Sci, Nottingham, England
dc.description.affiliationAston Univ, Sch Life & Hlth Sci, Birmingham, W Midlands, England
dc.description.affiliationUniv Southampton, Southampton, England
dc.description.affiliationUniv Sao Paulo, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Gothenburg, Gothenburg, Sweden
dc.description.affiliationUniv Oxford, Div Cardiovasc Med, Oxford, England
dc.description.affiliationUniv Oxford, Acute Stroke Programme, RDM Investigat Med, Oxford, England
dc.description.affiliationUniv Oxford, Sir William Dunn Sch Pathol, Oxford, England
dc.description.affiliationUniv St Andrews, St Andrews, Fife, Scotland
dc.description.affiliationUniv Fed Sao Paulo, Campus Diadema, Diadema, Brazil
dc.description.affiliationLondon Metropolitan Univ, London, England
dc.description.affiliationUniv Anhanguera Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationUniv Southern Denmark, Odense, Denmark
dc.description.affiliationTech Univ Munich, Munich, Germany
dc.description.affiliationUniv Glasgow, Inst Infect Immun & Inflammat, Glasgow, Lanark, Scotland
dc.description.affiliationOxford Brookes Univ, Oxford, England
dc.description.affiliationFdn Santa Lucia, IRCCS, Rome, Italy
dc.description.affiliationUnifespUniv Fed Sao Paulo, Campus Diadema, Diadema, Brazil
dc.description.provenanceMade available in DSpace on 2020-07-08T13:09:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2018. Added 1 bitstream(s) on 2020-07-08T13:33:34Z : No. of bitstreams: 1 WOS000423259000001.pdf: 1287687 bytes, checksum: 2a9b6d8f6cedc28eaaba619634328a09 (MD5)en
dc.description.sourceWeb of Science
dc.description.sponsorshipBritish Council/Newton Fund, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipAssociação Beneficente Alzira Denise Hertzog Silva (ABADHS), Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipRicerca Finalizzata from the Ministero della Salute, Italy
dc.description.sponsorshipScience without Borders/CAPES, Brazil
dc.description.sponsorshipIDBritish Council/Newton Fund, Brazil:203855854
dc.description.sponsorshipIDFAPESP: 2012/24574-3pt
dc.description.sponsorshipIDRicerca Finalizzata from the Ministero della Salute, Italy: 172/GR-2011-02350301it
dc.description.sponsorshipIDScience without Borders/CAPES, Brazil: BEX 7057/15-6pt
dc.description.sponsorshipIDFAPESP: 2015/50257-3pt
dc.description.sponsorshipIDFAPESP: 2014/26897-0pt
dc.description.sponsorshipIDFAPESP: 2014/06863-3pt
dc.description.sponsorshipIDCNPq: 441878/2014-8pt
dc.description.sponsorshipIDCNPq: 202077/2015-2pt
dc.format.extent881-906
dc.identifierhttps://dx.doi.org/10.1039/c7nr08360b
dc.identifier.citationNanoscale. Cambridge, v. 10, n. 3, p. 881-906, 2018.
dc.identifier.doi10.1039/c7nr08360b
dc.identifier.fileWOS000423259000001.pdf
dc.identifier.issn2040-3364
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54256
dc.identifier.wosWOS:000423259000001
dc.language.isoeng
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofNanoscale
dc.rightsAcesso aberto
dc.titleTechnical challenges of working with extracellular vesiclesen
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