Abnormal Epigenetic Regulation of Immune System during Aging

Abnormal Epigenetic Regulation of Immune System during Aging

Author Jasiulionis, Miriam G. Autor UNIFESP Google Scholar
Abstract Epigenetics refers to the study of mechanisms controlling the chromatin structure, which has fundamental role in the regulation of gene expression and genome stability. Epigenetic marks, such as DNA methylation and histone modifications, are established during embryonic development and epigenetic profiles are stably inherited during mitosis, ensuring cell differentiation and fate. Under the effect of intrinsic and extrinsic factors, such as metabolic profile, hormones, nutrition, drugs, smoke, and stress, epigenetic marks are actively modulated. In this sense, the lifestyle may affect significantly the epigenome, and as a result, the gene expression profile and cell function. Epigenetic alterations are a hallmark of aging and diseases, such as cancer. Among biological systems compromised with aging is the decline of immune response. Different regulators of immune response have their promoters and enhancers susceptible to the modulation by epigenetic marks, which is fundamental to the differentiation and function of immune cells. Consistent evidence has showed the regulation of innate immune cells, and T and B lymphocytes by epigenetic mechanisms. Therefore, age-dependent alterations in epigenetic marks may result in the decline of immune function and this might contribute to the increased incidence of diseases in old people. In order to maintain health, we need to better understand how to avoid epigenetic alterations related to immune aging. In this review, the contribution of epigenetic mechanisms to the loss of immune function during aging will be discussed, and the promise of new means of disease prevention and management will be pointed.
Keywords immune aging
DNA methylation
age-related diseases
xmlui.dri2xhtml.METS-1.0.item-coverage Lausanne
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2014/13663-0]
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [400036/2016-9]
Grant number FAPESP: 2014/13663-0
CNPq: 400036/2016-9
Date 2018
Published in Frontiers In Immunology. Lausanne, v. 9, p. -, 2018.
ISSN 1664-3224 (Sherpa/Romeo, impact factor)
Publisher Frontiers Media Sa
Extent -
Origin http://dx.doi.org/10.3389/fimmu.2018.00197
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000424780600001
URI https://repositorio.unifesp.br/handle/11600/54133

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