Abnormal Epigenetic Regulation of Immune System during Aging

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dc.citation.volume9
dc.contributor.authorJasiulionis, Miriam G. [UNIFESP]
dc.coverageLausanne
dc.date.accessioned2020-07-08T13:09:41Z
dc.date.available2020-07-08T13:09:41Z
dc.date.issued2018
dc.description.abstractEpigenetics refers to the study of mechanisms controlling the chromatin structure, which has fundamental role in the regulation of gene expression and genome stability. Epigenetic marks, such as DNA methylation and histone modifications, are established during embryonic development and epigenetic profiles are stably inherited during mitosis, ensuring cell differentiation and fate. Under the effect of intrinsic and extrinsic factors, such as metabolic profile, hormones, nutrition, drugs, smoke, and stress, epigenetic marks are actively modulated. In this sense, the lifestyle may affect significantly the epigenome, and as a result, the gene expression profile and cell function. Epigenetic alterations are a hallmark of aging and diseases, such as cancer. Among biological systems compromised with aging is the decline of immune response. Different regulators of immune response have their promoters and enhancers susceptible to the modulation by epigenetic marks, which is fundamental to the differentiation and function of immune cells. Consistent evidence has showed the regulation of innate immune cells, and T and B lymphocytes by epigenetic mechanisms. Therefore, age-dependent alterations in epigenetic marks may result in the decline of immune function and this might contribute to the increased incidence of diseases in old people. In order to maintain health, we need to better understand how to avoid epigenetic alterations related to immune aging. In this review, the contribution of epigenetic mechanisms to the loss of immune function during aging will be discussed, and the promise of new means of disease prevention and management will be pointed.en
dc.description.affiliationUniv Fed Sao Paulo, Pharmacol Dept, Lab Ontogeny & Epigenet, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Pharmacol Dept, Lab Ontogeny & Epigenet, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2014/13663-0]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [400036/2016-9]
dc.description.sponsorshipIDFAPESP: 2014/13663-0
dc.description.sponsorshipIDCNPq: 400036/2016-9
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fimmu.2018.00197
dc.identifier.citationFrontiers In Immunology. Lausanne, v. 9, p. -, 2018.
dc.identifier.doi10.3389/fimmu.2018.00197
dc.identifier.fileWOS000424780600001.pdf
dc.identifier.issn1664-3224
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54133
dc.identifier.wosWOS:000424780600001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Immunology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectimmune agingen
dc.subjectepigeneticsen
dc.subjectDNA methylationen
dc.subjecthistonesen
dc.subjectenvironmenten
dc.subjectage-related diseasesen
dc.titleAbnormal Epigenetic Regulation of Immune System during Agingen
dc.typeinfo:eu-repo/semantics/article
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