METABOLOMICS: DEFINITIONS, STATE-OF-THE-ART AND REPRESENTATIVE APPLICATIONS

METABOLOMICS: DEFINITIONS, STATE-OF-THE-ART AND REPRESENTATIVE APPLICATIONS

Author Canuto, Gisele A. B. Google Scholar
da Costa, Jose Luiz Google Scholar
da Cruz, Pedro L. R. Google Scholar
de Souza, Ana Rosa L. Google Scholar
Faccio, Andrea T. Google Scholar
Klassen, Aline Autor UNIFESP Google Scholar
Rodrigues, Karina T. Google Scholar
Tavares, Marina F. M. Google Scholar
Abstract Metabolomics is an emerging and promising omics approach used to understand biological mechanisms. By untargeted and targeted metabolomics analyses, metabolites are determined in biological samples (fluids, cells, tissues, etc.) by comparison of control groups with altered groups, undergoing different therapies, submitted to differing stress levels, dietary modulation, or promoted by a disease, or specific condition, etc., using sophisticated analytical techniques, and advanced data treatment and statistical analyses. In this review, the concepts involved in metabolomics studies were presented, describing in details all steps involved in the metabolomics workflow, for untargeted and targeted strategies. Finally, the potential of metabolomics is illustrated by applications in representative areas: clinical, environmental, food and nutrition, forensic toxicology, microbiology, parasitology, plants, and sports. Relevant reviews were compiled to characterize each of these areas, and a corresponding application of untargeted and targeted metabolomics were described.
Keywords metabolomics
untargeted metabolomics
targeted metabolomics
metabolomics workflow
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo
Language Portuguese
Date 2018
Published in Quimica Nova. Sao Paulo, v. 41, n. 1, p. 75-91, 2018.
ISSN 0100-4042 (Sherpa/Romeo, impact factor)
Publisher Soc Brasileira Quimica
Extent 75-91
Origin http://dx.doi.org/10.21577/0100-4042.20170134
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000425722500012
URI https://repositorio.unifesp.br/handle/11600/53856

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