METABOLOMICS: DEFINITIONS, STATE-OF-THE-ART AND REPRESENTATIVE APPLICATIONS

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dc.citation.issue1
dc.citation.volume41
dc.contributor.authorCanuto, Gisele A. B.
dc.contributor.authorda Costa, Jose Luiz
dc.contributor.authorda Cruz, Pedro L. R.
dc.contributor.authorde Souza, Ana Rosa L.
dc.contributor.authorFaccio, Andrea T.
dc.contributor.authorKlassen, Aline [UNIFESP]
dc.contributor.authorRodrigues, Karina T.
dc.contributor.authorTavares, Marina F. M.
dc.coverageSao Paulo
dc.date.accessioned2020-07-02T18:52:03Z
dc.date.available2020-07-02T18:52:03Z
dc.date.issued2018
dc.description.abstractMetabolomics is an emerging and promising omics approach used to understand biological mechanisms. By untargeted and targeted metabolomics analyses, metabolites are determined in biological samples (fluids, cells, tissues, etc.) by comparison of control groups with altered groups, undergoing different therapies, submitted to differing stress levels, dietary modulation, or promoted by a disease, or specific condition, etc., using sophisticated analytical techniques, and advanced data treatment and statistical analyses. In this review, the concepts involved in metabolomics studies were presented, describing in details all steps involved in the metabolomics workflow, for untargeted and targeted strategies. Finally, the potential of metabolomics is illustrated by applications in representative areas: clinical, environmental, food and nutrition, forensic toxicology, microbiology, parasitology, plants, and sports. Relevant reviews were compiled to characterize each of these areas, and a corresponding application of untargeted and targeted metabolomics were described.en
dc.description.affiliationUniv Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Fac Ciencias Farmaceut, Ctr Controle Intoxicacoes, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Quim, Campus Diadema, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Quim, Campus Diadema, BR-09972270 Diadema, SP, Brazil
dc.description.provenanceMade available in DSpace on 2020-07-02T18:52:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2018. Added 1 bitstream(s) on 2020-07-02T20:13:31Z : No. of bitstreams: 1 WOS000425722500012.pdf: 7313557 bytes, checksum: 82981d4d691024a0e6033c10131116e7 (MD5)en
dc.description.sourceWeb of Science
dc.format.extent75-91
dc.identifierhttp://dx.doi.org/10.21577/0100-4042.20170134
dc.identifier.citationQuimica Nova. Sao Paulo, v. 41, n. 1, p. 75-91, 2018.
dc.identifier.doi10.21577/0100-4042.20170134
dc.identifier.fileWOS000425722500012.pdf
dc.identifier.issn0100-4042
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53856
dc.identifier.wosWOS:000425722500012
dc.language.isopor
dc.publisherSoc Brasileira Quimica
dc.relation.ispartofQuimica Nova
dc.rightsAcesso aberto
dc.subjectmetabolomicsen
dc.subjectuntargeted metabolomicsen
dc.subjecttargeted metabolomicsen
dc.subjectmetabolomics workflowen
dc.titleMETABOLOMICS: DEFINITIONS, STATE-OF-THE-ART AND REPRESENTATIVE APPLICATIONSen
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