Variants in SNCA Gene Are Associated with Parkinson's Disease Risk and Cognitive Symptoms in a Brazilian Sample

Variants in SNCA Gene Are Associated with Parkinson's Disease Risk and Cognitive Symptoms in a Brazilian Sample

Author Campelo, Clarissa L. C. Google Scholar
Cagni, Fernanda C. Google Scholar
Figueredo, Diego de Siqueira Google Scholar
Oliveira, Luiz G., Jr. Google Scholar
Silva-Neto, Antonio B. Google Scholar
Macedo, Priscila T. Google Scholar
Santos, Jose R. Google Scholar
Izidio, Geison S. Google Scholar
Ribeiro, Alessandra M. Autor UNIFESP Google Scholar
de Andrade, Tiago G. Google Scholar
Godeiro, Clecio de Oliveira, Jr. Google Scholar
Silva, Regina H. Autor UNIFESP Google Scholar
Abstract Genetic susceptibility contributes to the etiology of sporadic Parkinson's Disease (PD) and worldwide studies have found positive associations of polymorphisms in the alphasynuclein gene (SNCA) with the risk for PD. However, little is known about the influence of variants of SNCA in individual traits or phenotypical aspects of PD. Further, there is a lack of studies with Latin-American samples. We evaluated the association between SNCA single nucleotide polymorphisms (single nucleotide polymorphisms, SNPs rs2583988, rs356219, rs2736990, and rs11931074) and PD risk in a Brazilians sample. In addition, we investigated their potential interactions with environmental factors and specific clinical outcomes (motor and cognitive impairments, depression, and anxiety). A total of 105 PD patients and 101 controls participated in the study. Single locus analysis showed that the risk allele of all SNPs were more frequent in PD patients (p < 0.05), and the associations of SNPs rs2583988, rs356219, and rs2736990 with increased PD risk were confirmed. Further, the G-rs356219 and C-rs2736990 alleles were associated with early onset PD. T-rs2583988, G-rs356219 and C-2736990 alleles were significantly more frequent in PD patients with cognitive impairments than controls in this condition. In addition, in a logistic regression model, we found an association of cognitive impairment with PD, and the practice of cognitive activity and smoking habits had a protective effect. This study shows for the first time an association of SNCA polymorphism and PD in a South-American sample. In addition, we found an interaction between SNP rs356219 and a specific clinical outcome, i.e., the increased risk for cognitive impairment in PD patients.
Keywords Parkinson's disease
alpha-synuclein
SNCA gene
polymorphism
cognitive impairment
clinical assessment
Brazil
xmlui.dri2xhtml.METS-1.0.item-coverage Lausanne
Language English
Sponsor Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Fundacao de Apoio a Pesquisa do Estado do Rio Grande do Norte (FAPERN/PRONEX)
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Grant number CNPq: 402054/2010-5
CAPES
FAPERN/PRONEX
FAPESP: 2015/12308-5
Date 2017
Published in Frontiers In Aging Neuroscience. Lausanne, v. 9, p. -, 2017.
ISSN 1663-4365 (Sherpa/Romeo, impact factor)
Publisher Frontiers Media Sa
Extent -
Origin http://dx.doi.org/10.3389/fnagi.2017.00198
Access rights ACESSO ABERTO
Type Article
Web of Science ID WOS:000403769800001
URI https://repositorio.unifesp.br/handle/11600/53647

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