Variants in SNCA Gene Are Associated with Parkinson's Disease Risk and Cognitive Symptoms in a Brazilian Sample

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dc.citation.volume9]
dc.contributor.authorCampelo, Clarissa Loureiro Chagas
dc.contributor.authorCagni, Fernanda Carvalho
dc.contributor.authorFigueredo, Diego de Siqueira
dc.contributor.authorOliveira Junior, Luiz Gonzaga
dc.contributor.authorSilva Neto, Antonio Braz
dc.contributor.authorMacedo, Priscila Tavares
dc.contributor.authorSantos, José Ronaldo dos
dc.contributor.authorIzídio, Geison Souza
dc.contributor.authorRibeiro, Alessandra Mussi [UNIFESP]
dc.contributor.authorAndrade, Tiago Gomes de
dc.contributor.authorGodeiro Junior, Clecio de Oliveira
dc.contributor.authorSilva, Regina Helena [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.coverageLausanne
dc.date.accessioned2020-06-26T16:30:36Z
dc.date.available2020-06-26T16:30:36Z
dc.date.issued2017
dc.description.abstractGenetic susceptibility contributes to the etiology of sporadic Parkinson's Disease (PD) and worldwide studies have found positive associations of polymorphisms in the alphasynuclein gene (SNCA) with the risk for PD. However, little is known about the influence of variants of SNCA in individual traits or phenotypical aspects of PD. Further, there is a lack of studies with Latin-American samples. We evaluated the association between SNCA single nucleotide polymorphisms (single nucleotide polymorphisms, SNPs rs2583988, rs356219, rs2736990, and rs11931074) and PD risk in a Brazilians sample. In addition, we investigated their potential interactions with environmental factors and specific clinical outcomes (motor and cognitive impairments, depression, and anxiety). A total of 105 PD patients and 101 controls participated in the study. Single locus analysis showed that the risk allele of all SNPs were more frequent in PD patients (p < 0.05), and the associations of SNPs rs2583988, rs356219, and rs2736990 with increased PD risk were confirmed. Further, the G-rs356219 and C-rs2736990 alleles were associated with early onset PD. T-rs2583988, G-rs356219 and C-2736990 alleles were significantly more frequent in PD patients with cognitive impairments than controls in this condition. In addition, in a logistic regression model, we found an association of cognitive impairment with PD, and the practice of cognitive activity and smoking habits had a protective effect. This study shows for the first time an association of SNCA polymorphism and PD in a South-American sample. In addition, we found an interaction between SNP rs356219 and a specific clinical outcome, i.e., the increased risk for cognitive impairment in PD patients.en
dc.description.affiliationUniv Fed Rio Grande do Norte, Physiol Dept, Memory Studies Lab, Natal, RN, Brazil
dc.description.affiliationUniv Fed Alagoas, Mol Biol & Gene Express Lab, Arapiraca, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Med Dept, Natal, RN, Brazil
dc.description.affiliationUniv Fed Santa Catarina, Dept Cell Biol Embryol & Genet, Florianopolis, SC, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Biosci Dept, Santos, Brazil
dc.description.affiliationUniv Fed Alagoas, Fac Med, Maceio, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Pharmacol Dept, Behav Neurosci Lab, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Biosci Dept, Santos, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Pharmacol Dept, Behav Neurosci Lab, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt
dc.description.sponsorshipFundação de Apoio à Pesquisa do Estado do Rio Grande do Norte (FAPERN/PRONEX)pt
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipIDCNPq: 402054/2010-5pt
dc.description.sponsorshipIDFAPESP: 2015/12308-5pt
dc.format.extent-
dc.identifierhttps://dx.doi.org/10.3389/fnagi.2017.00198]
dc.identifier.citationFrontiers In Aging Neuroscience. Lausanne, v. 9, p. -, 2017.
dc.identifier.doi10.3389/fnagi.2017.00198
dc.identifier.fileWOS000403769800001.pdf
dc.identifier.issn1663-4365
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53647
dc.identifier.wosWOS:000403769800001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Aging Neuroscience
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectParkinson's diseaseen
dc.subjectAlpha-synucleinen
dc.subjectSNCA geneen
dc.subjectPolymorphismen
dc.subjectCognitive impairmenten
dc.subjectClinical assessmenten
dc.subjectBrazilen
dc.titleVariants in SNCA Gene Are Associated with Parkinson's Disease Risk and Cognitive Symptoms in a Brazilian Sampleen
dc.typeinfo:eu-repo/semantics/article
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