(-)-Terpinen-4-ol changes intracellular Ca2+ handling and induces pacing disturbance in rat hearts

(-)-Terpinen-4-ol changes intracellular Ca2+ handling and induces pacing disturbance in rat hearts

Author Santana Gondim, Antonio Nei Google Scholar
Lara, Aline Google Scholar
Santos-Miranda, Artur Google Scholar
Roman-Campos, Danilo Autor UNIFESP Google Scholar
Lauton-Santos, Sandra Google Scholar
Rodrigues Menezes-Filho, Jose Evaldo Google Scholar
Lins de Vasconcelos, Carla Maria Google Scholar
Conde-Garcia, Eduardo Antonio Google Scholar
Guatimosim, Silvia Google Scholar
Cruz, Jader S. Google Scholar
Abstract (-)-Terpinen-4-ol is a naturally occurring plant monoterpene and has been shown to have a plethora of biological activities. The objective of this study was to investigate the effects of (-)-terpinen-4-ol on the rat heart, a key player in the control and maintenance of arterial blood pressure. The effects of (-)-terpinen-4-ol on the rat heart were investigated using isolated left atrium isometric force measurements, in vivo electrocardiogram (ECG) recordings, patch clamp technique, and confocal microscopy. It was observed that (-)-terpinen-4-ol reduced contraction force in an isolated left atrium at millimolar concentrations. Conversely, it induced a positive inotropic effect and extrasystoles at micromolar concentrations, suggesting that (-)-terpinen-4-ol may have arrhythmogenic activity on cardiac tissue. In anaesthetized animals, (-)-terpinen-4-ol also elicited rhythm disturbance, such as supraventricular tachycardia and atrioventricular block. To investigate the cellular mechanism underlying the dual effect of (-)-terpinen-4-ol on heart muscle, experiments were performed on isolated ventricular cardiomyocytes to determine the effect of (-)-terpinen-4-ol on L-type Ca2+ currents, Ca2+ sparks, and Ca2+ transients. The arrhythmogenic activity of (-)-terpinen-4-ol in vitro and in vivo may be explained by its effect on intracellular Ca2+ handling. Taken together, our data suggest that (-)-terpinen-4-ol has cardiac arrhythmogenic activity.
Keywords (-)-Terpinen-4-ol
Heart
Arrhythmia
Cardiac myocytes
Ca2+ current
Alpinia zerumbet
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Fundacao de Apoio a Pesquisa e Inovacao Tecnologica do Estado de Sergipe (FAPITEC/SE)
CNPq
FAPITEC Scholarship
Grant number FAPESP: 2014/09861-1
FAPITEC/SE: 07/2008
CNPq
FAPITEC Scholarship
Date 2017
Published in European Journal Of Pharmacology. Amsterdam, v. 807, p. 56-63, 2017.
ISSN 0014-2999 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 56-63
Origin http://dx.doi.org/10.1016/j.ejphar.2017.04.022
Access rights ACESSO RESTRITO
Type Article
Web of Science ID WOS:000403520300006
URI https://repositorio.unifesp.br/handle/11600/53447

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