(-)-Terpinen-4-ol changes intracellular Ca2+ handling and induces pacing disturbance in rat hearts

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dc.citation.volume807]
dc.contributor.authorSantana Gondim, Antonio Nei
dc.contributor.authorLara, Aline
dc.contributor.authorSantos-Miranda, Artur
dc.contributor.authorRoman-Campos, Danilo [UNIFESP]
dc.contributor.authorLauton-Santos, Sandra
dc.contributor.authorRodrigues Menezes-Filho, Jose Evaldo
dc.contributor.authorLins de Vasconcelos, Carla Maria
dc.contributor.authorConde-Garcia, Eduardo Antonio
dc.contributor.authorGuatimosim, Silvia
dc.contributor.authorCruz, Jader S.
dc.coverageAmsterdam
dc.date.accessioned2020-06-26T16:30:15Z
dc.date.available2020-06-26T16:30:15Z
dc.date.issued2017
dc.description.abstract(-)-Terpinen-4-ol is a naturally occurring plant monoterpene and has been shown to have a plethora of biological activities. The objective of this study was to investigate the effects of (-)-terpinen-4-ol on the rat heart, a key player in the control and maintenance of arterial blood pressure. The effects of (-)-terpinen-4-ol on the rat heart were investigated using isolated left atrium isometric force measurements, in vivo electrocardiogram (ECG) recordings, patch clamp technique, and confocal microscopy. It was observed that (-)-terpinen-4-ol reduced contraction force in an isolated left atrium at millimolar concentrations. Conversely, it induced a positive inotropic effect and extrasystoles at micromolar concentrations, suggesting that (-)-terpinen-4-ol may have arrhythmogenic activity on cardiac tissue. In anaesthetized animals, (-)-terpinen-4-ol also elicited rhythm disturbance, such as supraventricular tachycardia and atrioventricular block. To investigate the cellular mechanism underlying the dual effect of (-)-terpinen-4-ol on heart muscle, experiments were performed on isolated ventricular cardiomyocytes to determine the effect of (-)-terpinen-4-ol on L-type Ca2+ currents, Ca2+ sparks, and Ca2+ transients. The arrhythmogenic activity of (-)-terpinen-4-ol in vitro and in vivo may be explained by its effect on intracellular Ca2+ handling. Taken together, our data suggest that (-)-terpinen-4-ol has cardiac arrhythmogenic activity.en
dc.description.affiliationUniv Estado Bahia, Dept Educ, Campus 12,Av Vanessa Cardoso & Cardoso S-N, BR-46430000 Guanambi, BA, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Dept Bioquim & Imunol, Lab Membranes Excitaveis & Biol Cardiovasc, Av Antonio Carlos,6627 Pampulha,ICB Bloco K-4, BR-30161970 Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Dept Fisiol & Biofis, Av Antonio Carlos,6627 Pampulha,ICB Bloco D-4, BR-30161970 Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biofis, Lab Biofis, Rua Botucatu 862,Vila Clementino, BR-04023062 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sergipe, Dept Fisiol, Av Marechal Rondon S-N, BR-49100000 Sao Cristovao, SE, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biofis, Lab Biofis, Rua Botucatu 862,Vila Clementino, BR-04023062 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipFundacao de Apoio a Pesquisa e Inovacao Tecnologica do Estado de Sergipe (FAPITEC/SE)
dc.description.sponsorshipCNPq
dc.description.sponsorshipFAPITEC Scholarship
dc.description.sponsorshipIDFAPESP: 2014/09861-1
dc.description.sponsorshipIDFAPITEC/SE: 07/2008
dc.description.sponsorshipIDCNPq
dc.description.sponsorshipIDFAPITEC Scholarship
dc.format.extent56-63
dc.identifierhttp://dx.doi.org/10.1016/j.ejphar.2017.04.022]
dc.identifier.citationEuropean Journal Of Pharmacology. Amsterdam, v. 807, p. 56-63, 2017.
dc.identifier.doi10.1016/j.ejphar.2017.04.022
dc.identifier.issn0014-2999
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53447
dc.identifier.wosWOS:000403520300006
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofEuropean Journal Of Pharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subject(-)-Terpinen-4-olen
dc.subjectHearten
dc.subjectArrhythmiaen
dc.subjectCardiac myocytesen
dc.subjectCa2+ currenten
dc.subjectAlpinia zerumbeten
dc.title(-)-Terpinen-4-ol changes intracellular Ca2+ handling and induces pacing disturbance in rat heartsen
dc.typeinfo:eu-repo/semantics/article
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