In vivo analysis of glaucoma-related features within the optic nerve head using enhanced depth imaging optical coherence tomography

In vivo analysis of glaucoma-related features within the optic nerve head using enhanced depth imaging optical coherence tomography

Author Prata, Tiago S. Autor UNIFESP Google Scholar
Lopes, Flavio S. Autor UNIFESP Google Scholar
Prado, Vitor G. Autor UNIFESP Google Scholar
Almeida, Izabela Autor UNIFESP Google Scholar
Matsubara, Igor Autor UNIFESP Google Scholar
Dorairaj, Syril Google Scholar
Furlanetto, Rafael L. Autor UNIFESP Google Scholar
Vessani, Roberto M. Autor UNIFESP Google Scholar
Paranhos, Augusto, Jr. Autor UNIFESP Google Scholar
Abstract Structural differences between optic nerve head (ONH) parameters in glaucomatous and non-glaucomatous eyes has been documented, however the association between such parameters in patients with different disease stages is yet to be elucidated. We investigated the relationship between different laminar and prelaminar ONH structures using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT) in a population with and without glaucoma. In this observational case-control study, we prospectively enrolled healthy individuals and glaucomatous patients with different disease stages. All participants underwent EDI OCT imaging (Heidelberg Engineering). Following ONH parameters were measured on serial vertical B-scans by two examiners masked to patient's clinical data: lamina cribrosa (LC) and prelaminar neural tissue (PLNT) thicknesses, Bruch's membrane opening (BMO) and cup depth. Associations between cup depth, and laminar and prelaminar parameters were evaluated controlling for possible confounding factors such as axial length and disc size. Sixty-four eyes of 64 patients were included (30 with glaucoma and 34 controls). Eyes with glaucoma had significantly lower mean LC and PLNT thickness, and greater mean cup depth than controls (p<0.01). There was a significant negative association between PLNT thickness and cup depth in glaucomatous eyes (R-2 = 0.158, p = 0.029). In addition, LC thickness correlated significantly with cup depth (R-2 = 0.135, p = 0.045). Eyes with thinner LCs presented deeper cups. Overall, cup depth and BMO had the best and LC thickness had the worst intraobserver and interobserver reproducibility grading. In conclusion, significant associations were seen between cup depth, LC and PLNT thickness. Eyes with deeper cups not only had less neural tissue, but also thinner LCs, independent of disc size and axial length. Best reproducibility was found for prelaminar parameters compared to deeper ONH structures.
xmlui.dri2xhtml.METS-1.0.item-coverage San Francisco
Language English
Date 2017
Published in Plos One. San Francisco, v. 12, n. 7, p. -, 2017.
ISSN 1932-6203 (Sherpa/Romeo, impact factor)
Publisher Public Library Science
Extent -
Access rights ACESSO ABERTO
Type Article
Web of Science ID WOS:000406643100003

Show full item record


Name: WOS000406643100003.pdf
Size: 4.661Mb
Format: PDF
Open file

This item appears in the following Collection(s)




My Account