In vivo analysis of glaucoma-related features within the optic nerve head using enhanced depth imaging optical coherence tomography

Página do item simplificado
dc.citation.issue7]
dc.citation.volume12]
dc.contributor.authorPrata, Tiago S. [UNIFESP]
dc.contributor.authorLopes, Flavio S. [UNIFESP]
dc.contributor.authorPrado, Vitor G. [UNIFESP]
dc.contributor.authorAlmeida, Izabela [UNIFESP]
dc.contributor.authorMatsubara, Igor [UNIFESP]
dc.contributor.authorDorairaj, Syril
dc.contributor.authorFurlanetto, Rafael L. [UNIFESP]
dc.contributor.authorVessani, Roberto M. [UNIFESP]
dc.contributor.authorParanhos, Augusto, Jr. [UNIFESP]
dc.coverageSan Francisco
dc.date.accessioned2020-06-26T16:30:14Z
dc.date.available2020-06-26T16:30:14Z
dc.date.issued2017
dc.description.abstractStructural differences between optic nerve head (ONH) parameters in glaucomatous and non-glaucomatous eyes has been documented, however the association between such parameters in patients with different disease stages is yet to be elucidated. We investigated the relationship between different laminar and prelaminar ONH structures using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT) in a population with and without glaucoma. In this observational case-control study, we prospectively enrolled healthy individuals and glaucomatous patients with different disease stages. All participants underwent EDI OCT imaging (Heidelberg Engineering). Following ONH parameters were measured on serial vertical B-scans by two examiners masked to patient's clinical data: lamina cribrosa (LC) and prelaminar neural tissue (PLNT) thicknesses, Bruch's membrane opening (BMO) and cup depth. Associations between cup depth, and laminar and prelaminar parameters were evaluated controlling for possible confounding factors such as axial length and disc size. Sixty-four eyes of 64 patients were included (30 with glaucoma and 34 controls). Eyes with glaucoma had significantly lower mean LC and PLNT thickness, and greater mean cup depth than controls (p<0.01). There was a significant negative association between PLNT thickness and cup depth in glaucomatous eyes (R-2 = 0.158, p = 0.029). In addition, LC thickness correlated significantly with cup depth (R-2 = 0.135, p = 0.045). Eyes with thinner LCs presented deeper cups. Overall, cup depth and BMO had the best and LC thickness had the worst intraobserver and interobserver reproducibility grading. In conclusion, significant associations were seen between cup depth, LC and PLNT thickness. Eyes with deeper cups not only had less neural tissue, but also thinner LCs, independent of disc size and axial length. Best reproducibility was found for prelaminar parameters compared to deeper ONH structures.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Ophthalmol, Glaucoma Serv, Sao Paulo, Brazil
dc.description.affiliationHosp Med Olhos, Glaucoma Unit, Osasco, Brazil
dc.description.affiliationMayo Clin, Jacksonville, FL 32224 USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ophthalmol, Glaucoma Serv, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0180128]
dc.identifier.citationPlos One. San Francisco, v. 12, n. 7, p. -, 2017.
dc.identifier.doi10.1371/journal.pone.0180128
dc.identifier.fileWOS000406643100003.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53438
dc.identifier.wosWOS:000406643100003
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleIn vivo analysis of glaucoma-related features within the optic nerve head using enhanced depth imaging optical coherence tomographyen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000406643100003.pdf
Tamanho:
4.45 MB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos