Can breast tumors affect the oxidative status of the surrounding environment? A comparative analysis among cancerous breast, mammary adjacent tissue, and plasma
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2016
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Panis, C.
Victorino, V. J.
Herrera, A. C. S. A.
Cecchini, A. L.
Simao, A. N. C.
Tomita, L. Y. [UNIFESP]
Cecchini, R.
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In this paper, we investigated the oxidative profile of breast tumors in comparison with their normal adjacent breast tissue. Our study indicates that breast tumors present enhanced oxidative/nitrosative stress, with concomitant augmented antioxidant capacity when compared to the adjacent normal breast. These data indicate that breast cancers may be responsible for the induction of a prooxidant environment in the mammary gland, in association with enhanced TNF-alpha and nitric oxide.
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Oxidative Medicine And Cellular Longevity. London, 2016.