Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats

Date
2016Author
Assis, Livia [UNIFESP]
Milares, Luiz Paulo [UNIFESP]
Almeida, Thais [UNIFESP]
Tim, Carla
Magri, Angela Maria Paiva [UNIFESP]
Fernandes, Kelly Rossetti [UNIFESP]
Medalha, Carla Christina [UNIFESP]
Renno, Ana Claudia Muniz [UNIFESP]
Type
ArtigoISSN
1063-4584Is part of
Osteoarthritis And CartilageDOI
10.1016/j.joca.2015.07.020Metadata
Show full item recordAbstract
Objective: The aim of this study was to evaluate the effects of an aerobic exercise training and low-level laser therapy (LLLT) (associated or not) on degenerative modifications and inflammatory mediators on the articular cartilage using an experimental model of knee OA. Material and methods: Fifty male Wistar rats were randomly divided into five groups: control group (CG) knee OA control group (OAC) OA plus exercise training group (OAT) OA plus LLLT group (OAL) OA plus exercise training associated with LLLT group (OATL). The exercise training (treadmill 16 m/min 50 min/day) and the laser irradiation (two points-medial and lateral side of the left joint 24 sessions) started 4 weeks after the surgery, 3 days/week for 8 weeks. Results: The results showed that all treated groups showed (irradiated or not) a better pattern of tissue organization, with less fibrillation and irregularities along the articular surface and chondrocytes organization, a lower degenerative process measured by OARSI score and higher thickness values. Additionally, all treated group showed a reduced expression in IL-1 beta, caspase-3 and MMP-13 compared to OAC. Moreover, a lower caspase-3 expression was observed in OATL compared to OAL and OAT. Conclusion: These results suggest that exercise training and LLLT were effective in preventing cartilage degeneration and modulating inflammatory process induced by knee OA.
Citation
Osteoarthritis And Cartilage. Oxford, v. 24, n. 1, p. 169-177, 2016.Keywords
Low-level laser therapyArticular cartilage
Knee osteoarthritis
RehabilitationCartilage Matrix Degradation
Biomechanical Signals
Oxidative Stress
Controlled-Trial
Joint
Expression
Protocol
Pain
Apoptosis
Rabbit
Sponsorship
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Collections
- ISS - Artigos [738]
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