Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats

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dc.contributor.authorAssis, Livia [UNIFESP]
dc.contributor.authorMilares, Luiz Paulo [UNIFESP]
dc.contributor.authorAlmeida, Thais [UNIFESP]
dc.contributor.authorTim, Carla
dc.contributor.authorMagri, Angela Maria Paiva [UNIFESP]
dc.contributor.authorFernandes, Kelly Rossetti [UNIFESP]
dc.contributor.authorMedalha, Carla Christina [UNIFESP]
dc.contributor.authorRenno, Ana Claudia Muniz [UNIFESP]
dc.date.accessioned2018-07-26T17:30:30Z
dc.date.available2018-07-26T17:30:30Z
dc.date.issued2016
dc.description.abstractObjective: The aim of this study was to evaluate the effects of an aerobic exercise training and low-level laser therapy (LLLT) (associated or not) on degenerative modifications and inflammatory mediators on the articular cartilage using an experimental model of knee OA. Material and methods: Fifty male Wistar rats were randomly divided into five groups: control group (CG) knee OA control group (OAC) OA plus exercise training group (OAT) OA plus LLLT group (OAL) OA plus exercise training associated with LLLT group (OATL). The exercise training (treadmill 16 m/min 50 min/day) and the laser irradiation (two points-medial and lateral side of the left joint 24 sessions) started 4 weeks after the surgery, 3 days/week for 8 weeks. Results: The results showed that all treated groups showed (irradiated or not) a better pattern of tissue organization, with less fibrillation and irregularities along the articular surface and chondrocytes organization, a lower degenerative process measured by OARSI score and higher thickness values. Additionally, all treated group showed a reduced expression in IL-1 beta, caspase-3 and MMP-13 compared to OAC. Moreover, a lower caspase-3 expression was observed in OATL compared to OAL and OAT. Conclusion: These results suggest that exercise training and LLLT were effective in preventing cartilage degeneration and modulating inflammatory process induced by knee OA.en
dc.description.affiliationDepartment of Bioscience, Federal University of São Paulo, 11015020 Santos, SP, Brazil
dc.description.affiliationDepartment of Physiotherapy, Federal University of São Carlos, São Carlos, SP, Brazil
dc.description.affiliationUnifespDepartment of Bioscience, Federal University of São Paulo, R Silva Jardim 136, BR-11015020 Santos, SP, Brazil.
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2012-20145-0
dc.format.extent169-177
dc.identifierhttps://dx.doi.org/10.1016/j.joca.2015.07.020
dc.identifier.citationOsteoarthritis And Cartilage. Oxford, v. 24, n. 1, p. 169-177, 2016.
dc.identifier.doi10.1016/j.joca.2015.07.020
dc.identifier.issn1063-4584
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/46087
dc.identifier.wosWOS:000366839100020
dc.language.isoeng
dc.publisherElsevier Sci Ltd
dc.relation.ispartofOsteoarthritis And Cartilage
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLow-level laser therapyen
dc.subjectArticular cartilageen
dc.subjectKnee osteoarthritisen
dc.subjectRehabilitationCartilage Matrix Degradationen
dc.subjectBiomechanical Signalsen
dc.subjectOxidative Stressen
dc.subjectControlled-Trialen
dc.subjectJointen
dc.subjectExpressionen
dc.subjectProtocolen
dc.subjectPainen
dc.subjectApoptosisen
dc.subjectRabbiten
dc.titleAerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in ratsen
dc.typeinfo:eu-repo/semantics/article
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