Rapid Eye Movement Sleep Behavior Disorder in Paraneoplastic Cerebellar Degeneration: Improvement with Immunotherapy
Data
2016
Autores
Prado, Lucila Bizari Fernandes do 
Prado, Gilmar Fernandes do
Barsottini, Orlando Graziani Povoas
Pedroso, Jose Luiz
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Study Objectives: To report two female patients with paraneoplastic cerebellar degeneration (PCD) related to breast cancer that presented with rapid eye movement-sleep behavior disorder (RBD) and improved sleep symptoms with immunotherapy. Methods: The two patients were evaluated through clinical scale and polysomnography before and after therapy with intravenous immunoglobulin. Results: RBD was successfully treated with immunotherapy in both patients. Score on the RBD screening questionnaire dropped from 10 to 1 or 0, allied with the normalization of polysomnographic findings. Conclusions: A marked improvement in RBD after immunotherapy in PCD raises the hypothesis that secondary RBD may be an immune-mediated sleep disorder.
Descrição
Citação
Sleep. Westchester, v. 39, n. 1, p. 117-120, 2016.