Rapid Eye Movement Sleep Behavior Disorder in Paraneoplastic Cerebellar Degeneration: Improvement with Immunotherapy
| dc.contributor.author | Vale, Thiago Cardoso | |
| dc.contributor.author | Prado, Lucila Bizari Fernandes do [UNIFESP] | |
| dc.contributor.author | Prado, Gilmar Fernandes do [UNIFESP] | |
| dc.contributor.author | Barsottini, Orlando Graziani Povoas [UNIFESP] | |
| dc.contributor.author | Pedroso, Jose Luiz [UNIFESP] | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.date.accessioned | 2018-07-26T17:30:26Z | |
| dc.date.available | 2018-07-26T17:30:26Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | Study Objectives: To report two female patients with paraneoplastic cerebellar degeneration (PCD) related to breast cancer that presented with rapid eye movement-sleep behavior disorder (RBD) and improved sleep symptoms with immunotherapy. Methods: The two patients were evaluated through clinical scale and polysomnography before and after therapy with intravenous immunoglobulin. Results: RBD was successfully treated with immunotherapy in both patients. Score on the RBD screening questionnaire dropped from 10 to 1 or 0, allied with the normalization of polysomnographic findings. Conclusions: A marked improvement in RBD after immunotherapy in PCD raises the hypothesis that secondary RBD may be an immune-mediated sleep disorder. | en |
| dc.description.affiliation | Fed Univ Juiz de Fora UFJF, Fac Med, Dept Internal Med, Movement Disorders Unit,Neurol Serv,Univ Hosp, Juiz De Fora, MG, Brazil | |
| dc.description.affiliation | Univ Fed Sao Paulo, Dept Neurol, Div Gen Neurol, Sao Paulo, Brazil | |
| dc.description.affiliation | Univ Fed Sao Paulo, Dept Neurol, Ataxia Unit, Sao Paulo, Brazil | |
| dc.description.affiliationUnifesp | Division of General Neurology and Ataxia Unit, Department of Neurology, Universidade Federal São Paulo, São Paulo, Brazil | |
| dc.description.source | Web of Science | |
| dc.format.extent | 117-120 | |
| dc.identifier | https://dx.doi.org/10.5665/sleep.5330 | |
| dc.identifier.citation | Sleep. Westchester, v. 39, n. 1, p. 117-120, 2016. | |
| dc.identifier.doi | 10.5665/sleep.5330 | |
| dc.identifier.issn | 0161-8105 | |
| dc.identifier.uri | https://repositorio.unifesp.br/handle/11600/46068 | |
| dc.identifier.wos | WOS:000367515700017 | |
| dc.language.iso | eng | |
| dc.publisher | Amer Acad Sleep Medicine | |
| dc.relation.ispartof | Sleep | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Immunotherapy | en |
| dc.subject | Paraneoplastic cerebellar degeneration | en |
| dc.subject | REM sleep | en |
| dc.subject | REM-sleep behavior disorderRem-Sleep | en |
| dc.subject | Limbic Encephalitis | en |
| dc.subject | Antibodies | en |
| dc.subject | Ataxia | en |
| dc.title | Rapid Eye Movement Sleep Behavior Disorder in Paraneoplastic Cerebellar Degeneration: Improvement with Immunotherapy | en |
| dc.type | info:eu-repo/semantics/article |