Influence of temporomandibular joint pain on sleep patterns: Role of nitric oxide
Data
2004-09-01
Autores
Schütz, Teresa Cristina Barros 
Andersen, Monica Levy
Tufik, Sergio
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Since nitric oxide is related to nociception and the sleep- wake cycle, this study sought to determine its involvement in the altered sleep pattern in a temporomandibular joint pain model by investigating the effect of the inhibitor of nitric oxide synthase ( L- NAME) and that of its precursor ( L- arginine). The temporomandibular joints of test animals were injected with Freund's adjuvant or saline, and their sleep was recorded. The procedure was repeated after the administration of L- NAME and L- arginine. L-NAME increased rapid eye movement ( REM) sleep in the control group. The orofacial pain group showed a reduction in total sleep time and an increase in sleep latency compared with the SHAM group. L- NAME increased sleep time, non- rapid eye movement ( NREM), and REM sleep and reduced sleep latency in the orofacial pain group. L- arginine did not alter sleep parameters. Thus, L- NAME improved sleep efficiency, whereas L- arginine did not modify it, suggesting the involvement of nitric oxide in painful temporomandibular joint conditions.
Descrição
Citação
Journal Of Dental Research. Alexandria: Int Amer Assoc Dental Researchi A D R/a A D R, v. 83, n. 9, p. 693-697, 2004.