Influence of temporomandibular joint pain on sleep patterns: Role of nitric oxide

Página do item simplificado
dc.contributor.authorSchütz, Teresa Cristina Barros [UNIFESP]
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:58:42Z
dc.date.available2018-06-15T17:58:42Z
dc.date.issued2004-09-01
dc.description.abstractSince nitric oxide is related to nociception and the sleep- wake cycle, this study sought to determine its involvement in the altered sleep pattern in a temporomandibular joint pain model by investigating the effect of the inhibitor of nitric oxide synthase ( L- NAME) and that of its precursor ( L- arginine). The temporomandibular joints of test animals were injected with Freund's adjuvant or saline, and their sleep was recorded. The procedure was repeated after the administration of L- NAME and L- arginine. L-NAME increased rapid eye movement ( REM) sleep in the control group. The orofacial pain group showed a reduction in total sleep time and an increase in sleep latency compared with the SHAM group. L- NAME increased sleep time, non- rapid eye movement ( NREM), and REM sleep and reduced sleep latency in the orofacial pain group. L- arginine did not alter sleep parameters. Thus, L- NAME improved sleep efficiency, whereas L- arginine did not modify it, suggesting the involvement of nitric oxide in painful temporomandibular joint conditions.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Escola Paulista Med, UNIFESP EPM, BR-04024002 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, Escola Paulista Med, UNIFESP EPM, BR-04024002 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent693-697
dc.identifierhttps://dx.doi.org/10.1177/154405910408300907
dc.identifier.citationJournal Of Dental Research. Alexandria: Int Amer Assoc Dental Researchi A D R/a A D R, v. 83, n. 9, p. 693-697, 2004.
dc.identifier.doi10.1177/154405910408300907
dc.identifier.issn0022-0345
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/44342
dc.identifier.wosWOS:000227667700007
dc.language.isoeng
dc.publisherInt Amer Assoc Dental Researchi A D R/a A D R
dc.relation.ispartofJournal Of Dental Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOrofacial painen
dc.subjectSleepen
dc.subjectNitric oxideen
dc.subjectL-NAMEen
dc.subjectL-arginineen
dc.subjectRaten
dc.titleInfluence of temporomandibular joint pain on sleep patterns: Role of nitric oxideen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos