The Role of Metalloendopeptidases in Oropharyngeal Carcinomas Assessed by Tissue Microarray

The Role of Metalloendopeptidases in Oropharyngeal Carcinomas Assessed by Tissue Microarray

Author Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Nascimento, Fábio Dupart Autor UNIFESP Google Scholar
Fracalossi, Ana Carolina Cuzzuol Autor UNIFESP Google Scholar
Noguti, Juliana Autor UNIFESP Google Scholar
Oshima, Celina Tizuko Fujiyama Autor UNIFESP Google Scholar
Ihara, Silvia Saiuli Miki Autor UNIFESP Google Scholar
Franco, Marcello Fabiano de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The goal of this study was to investigate the expression of some metalloendopeptidases in squamous cell carcinomas of the oropharynx as well as its relation to histological differentiation, staging of disease, and prognosis. Paraffin blocks from 21 primary tumors were obtained from archives of the Department of Pathology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP/EPM. Immunohistochemistry was used to detect the expression of EP24.15 and EP24.16 by means of tissue microarrays. Expression of EP24.15 or EP24.16 was not correlated with the stage of disease, histopathological grading or recurrence in squamous cell carcinomas of the oropharynx. In summary, our results support the notion that EP24.15 and EP24.16 are expressed in carcinoma of the oropharynx; however, these do not appear to be suitable biomarkers for histological grading, disease stage or recurrence as depicted by tissue microarrays and immunohistochemistry.
Keywords Squamous cell carcinomas
tissue microarray
Language English
Date 2011-11-01
Published in Cancer Genomics & Proteomics. Athens: Int Inst Anticancer Research, v. 8, n. 6, p. 307-310, 2011.
ISSN 1109-6535 (Sherpa/Romeo, impact factor)
Publisher Int Inst Anticancer Research
Extent 307-310
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000296994600003

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