The Role of Metalloendopeptidases in Oropharyngeal Carcinomas Assessed by Tissue Microarray

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dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.authorNascimento, Fábio Dupart [UNIFESP]
dc.contributor.authorFracalossi, Ana Carolina Cuzzuol [UNIFESP]
dc.contributor.authorNoguti, Juliana [UNIFESP]
dc.contributor.authorOshima, Celina Tizuko Fujiyama [UNIFESP]
dc.contributor.authorIhara, Silvia Saiuli Miki [UNIFESP]
dc.contributor.authorFranco, Marcello Fabiano de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T16:39:13Z
dc.date.available2018-06-15T16:39:13Z
dc.date.issued2011-11-01
dc.description.abstractThe goal of this study was to investigate the expression of some metalloendopeptidases in squamous cell carcinomas of the oropharynx as well as its relation to histological differentiation, staging of disease, and prognosis. Paraffin blocks from 21 primary tumors were obtained from archives of the Department of Pathology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP/EPM. Immunohistochemistry was used to detect the expression of EP24.15 and EP24.16 by means of tissue microarrays. Expression of EP24.15 or EP24.16 was not correlated with the stage of disease, histopathological grading or recurrence in squamous cell carcinomas of the oropharynx. In summary, our results support the notion that EP24.15 and EP24.16 are expressed in carcinoma of the oropharynx; however, these do not appear to be suitable biomarkers for histological grading, disease stage or recurrence as depicted by tissue microarrays and immunohistochemistry.en
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Dept Biosci, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Dept Pathol, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP, Dept Biosci, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP, Dept Pathol, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent307-310
dc.identifierhttps://cgp.iiarjournals.org/content/8/6/307.full.pdf
dc.identifier.citationCancer Genomics & Proteomics. Athens: Int Inst Anticancer Research, v. 8, n. 6, p. 307-310, 2011.
dc.identifier.issn1109-6535
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/43241
dc.identifier.wosWOS:000296994600003
dc.language.isoeng
dc.publisherInt Inst Anticancer Research
dc.relation.ispartofCancer Genomics & Proteomics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSquamous cell carcinomasen
dc.subjecttissue microarrayen
dc.subjectmetalloendopeptidasesen
dc.titleThe Role of Metalloendopeptidases in Oropharyngeal Carcinomas Assessed by Tissue Microarrayen
dc.typeinfo:eu-repo/semantics/article
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