Can high altitude influence cytokines and sleep?

Can high altitude influence cytokines and sleep?

Author Lemos, Valdir de Aquino Autor UNIFESP Google Scholar
Santos, Ronaldo Vagner Thomatieli dos Autor UNIFESP Google Scholar
Lira, Fabio Santos de Autor UNIFESP Google Scholar
Rodrigues, Bruno Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Sao Judas Tadeu
Universidade de São Paulo (USP)
Abstract The number of persons who relocate to regions of high altitude for work, pleasure, sport, or residence increases every year. It is known that the reduced supply of oxygen (O-2) induced by acute or chronic increases in altitude stimulates the body to adapt to new metabolic challenges imposed by hypoxia. Sleep can suffer partial fragmentation because of the exposure to high altitudes, and these changes have been described as one of the responsible factors for the many consequences at high altitudes. We conducted a review of the literature during the period from 1987 to 2012. This work explored the relationships among inflammation, hypoxia and sleep in the period of adaptation and examined a novel mechanism that might explain the harmful effects of altitude on sleep, involving increased Interleukin-1 beta (IL-1 beta), Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) production from several tissues and cells, such as leukocytes and cells from skeletal muscle and brain.
Language English
Date 2013-01-01
Published in Mediators of Inflammation. New York: Hindawi Publishing Corporation, 8 p., 2013.
ISSN 0962-9351 (Sherpa/Romeo, impact factor)
Publisher Hindawi Publishing Corporation
Extent 8
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000317766600001

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