Can high altitude influence cytokines and sleep?

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dc.contributor.authorLemos, Valdir de Aquino [UNIFESP]
dc.contributor.authorSantos, Ronaldo Vagner Thomatieli dos [UNIFESP]
dc.contributor.authorLira, Fabio Santos de [UNIFESP]
dc.contributor.authorRodrigues, Bruno
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCEPE
dc.contributor.institutionUniv Sao Judas Tadeu
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:30:53Z
dc.date.available2016-01-24T14:30:53Z
dc.date.issued2013-01-01
dc.description.abstractThe number of persons who relocate to regions of high altitude for work, pleasure, sport, or residence increases every year. It is known that the reduced supply of oxygen (O-2) induced by acute or chronic increases in altitude stimulates the body to adapt to new metabolic challenges imposed by hypoxia. Sleep can suffer partial fragmentation because of the exposure to high altitudes, and these changes have been described as one of the responsible factors for the many consequences at high altitudes. We conducted a review of the literature during the period from 1987 to 2012. This work explored the relationships among inflammation, hypoxia and sleep in the period of adaptation and examined a novel mechanism that might explain the harmful effects of altitude on sleep, involving increased Interleukin-1 beta (IL-1 beta), Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) production from several tissues and cells, such as leukocytes and cells from skeletal muscle and brain.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationCEPE, São Paulo, Brazil
dc.description.affiliationUNIFESP, Dept Biociencias, BR-11030400 Santos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Ctr Estudos Psicobiol & Exercicio, São Paulo, Brazil
dc.description.affiliationUniv Sao Judas Tadeu, Lab Movimento Humano, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Inst Coracao InCor, Unidade Hipertensao, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, Dept Biociencias, BR-11030400 Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Ctr Estudos Psicobiol & Exercicio, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent8
dc.identifierhttps://dx.doi.org/10.1155/2013/279365
dc.identifier.citationMediators of Inflammation. New York: Hindawi Publishing Corporation, 8 p., 2013.
dc.identifier.doi10.1155/2013/279365
dc.identifier.fileWOS000317766600001.pdf
dc.identifier.issn0962-9351
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/35687
dc.identifier.wosWOS:000317766600001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofMediators of Inflammation
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleCan high altitude influence cytokines and sleep?en
dc.typeinfo:eu-repo/semantics/article
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