Gut-central nervous system axis is a target for nutritional therapies

Gut-central nervous system axis is a target for nutritional therapies

Author Pimentel, Gustavo Duarte Autor UNIFESP Google Scholar
Micheletti, Thayana O. Google Scholar
Pace, Fernanda Google Scholar
Rosa Neto, José Cesar Autor UNIFESP Google Scholar
Santos, Ronaldo Vagner Thomatieli dos Autor UNIFESP Google Scholar
Lira, Fabio Santos de Autor UNIFESP Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ So Santa Catarina UNESC
Jose Caetano de Lima
Abstract Historically, in the 1950s, the chemist Linus Pauling established a relationship between decreased longevity and obesity. At this time, with the advent of studies involving the mechanisms that modulate appetite control, some researchers observed that the hypothalamus is the appetite centre and that peripheral tissues have important roles in the modulation of gut inflammatory processes and levels of hormones that control food intake. Likewise, the advances of physiological and molecular mechanisms for patients with obesity, type 2 diabetes mellitus, inflammatory bowel diseases, bariatric surgery and anorexia-associated diseases has been greatly appreciated by nutritionists. Therefore, this review highlights the relationship between the gut-central nervous system axis and targets for nutritional therapies.
Keywords Gut
Central nervous system
Inflammatory disease
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2012-04-10
Published in Nutrition Journal. London: Biomed Central Ltd, v. 11, 9 p., 2012.
ISSN 1475-2891 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 9
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000304051700001

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