Depot-specific modulation of adipokine levels in rat adipose tissue by diet-induced obesity: the effect of aerobic training and energy restriction

Depot-specific modulation of adipokine levels in rat adipose tissue by diet-induced obesity: the effect of aerobic training and energy restriction

Author Yamashita, Alex Shimura Google Scholar
Lira, Fabio Santos de Autor UNIFESP Google Scholar
Rosa Neto, José Cesar Autor UNIFESP Google Scholar
Paulino, Ellena Christina Google Scholar
Brum, Patricia Chakur Google Scholar
Negrao, Carlos Eduardo Google Scholar
Santos, Ronaldo Vagner Thomatieli dos Autor UNIFESP Google Scholar
Batista, Miguel Luiz Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Seelaender, Marilia Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract The present study examined the effects of aerobic training and energy restriction on adipokines levels in mesenteric (MEAT) and retroperitoneal (RPAT) white adipose tissue from obese rats. Male Wistar rats were fed with standard laboratory diet (Control group) or high fat diet (HFD). After 15 weeks, HFD rats were randomly assigned to the following groups: rats submitted to HFD, which were sedentary (sedentary HFD, n = 8) or trained (trained HFD, n = 8); or submitted to energy-restriction (ER), which were sedentary (sedentary ER, n = 8) or trained (trained ER, n = 8). Trained rats ran on a treadmill at 55% VO2max for 60 min/day, 5 days/week, for 10 weeks. ER rats were submitted to a reduction of 20% daily caloric ingestion compared to the Control group. ER and aerobic training decreased body weight, MEAT and RPAT absolute weight, and fat mass. IL-6, IL-10 and TNF-alpha levels were decreased and adiponectin did not change in RPAT in response to ER protocol. On the other hand, ER and the aerobic training protocol decreased IL-6, TNF-alpha and adiponectin levels in MEAT. Absolute MEAT weight showed a positive correlation with IL-6 (r = 0.464), INF-alpha (r = 0.508); and adiponectin (r = 0.342). These results suggest a tissue-specific heterogeneous response in adipokines level. the combination of the protocols (aerobic training and energy restriction) did not induce an enhanced effect. Published by Elsevier B.V.
Keywords White adipose tissue
Energy restriction
Aerobic training
Adipokines
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 04/11588-0
FAPESP: 05/01445-0
Date 2010-12-01
Published in Cytokine. London: Academic Press Ltd- Elsevier B.V., v. 52, n. 3, p. 168-174, 2010.
ISSN 1043-4666 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 168-174
Origin https://dx.doi.org/10.1016/j.cyto.2010.07.006
Access rights Closed access
Type Article
Web of Science ID WOS:000284819300006
URI https://repositorio.unifesp.br/handle/11600/33123

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