Depot-specific modulation of adipokine levels in rat adipose tissue by diet-induced obesity: the effect of aerobic training and energy restriction

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dc.contributor.authorYamashita, Alex Shimura
dc.contributor.authorLira, Fabio Santos de [UNIFESP]
dc.contributor.authorRosa Neto, José Cesar [UNIFESP]
dc.contributor.authorPaulino, Ellena Christina
dc.contributor.authorBrum, Patricia Chakur
dc.contributor.authorNegrao, Carlos Eduardo
dc.contributor.authorSantos, Ronaldo Vagner Thomatieli dos [UNIFESP]
dc.contributor.authorBatista, Miguel Luiz
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorSeelaender, Marilia
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:05:44Z
dc.date.available2016-01-24T14:05:44Z
dc.date.issued2010-12-01
dc.description.abstractThe present study examined the effects of aerobic training and energy restriction on adipokines levels in mesenteric (MEAT) and retroperitoneal (RPAT) white adipose tissue from obese rats. Male Wistar rats were fed with standard laboratory diet (Control group) or high fat diet (HFD). After 15 weeks, HFD rats were randomly assigned to the following groups: rats submitted to HFD, which were sedentary (sedentary HFD, n = 8) or trained (trained HFD, n = 8); or submitted to energy-restriction (ER), which were sedentary (sedentary ER, n = 8) or trained (trained ER, n = 8). Trained rats ran on a treadmill at 55% VO2max for 60 min/day, 5 days/week, for 10 weeks. ER rats were submitted to a reduction of 20% daily caloric ingestion compared to the Control group. ER and aerobic training decreased body weight, MEAT and RPAT absolute weight, and fat mass. IL-6, IL-10 and TNF-alpha levels were decreased and adiponectin did not change in RPAT in response to ER protocol. On the other hand, ER and the aerobic training protocol decreased IL-6, TNF-alpha and adiponectin levels in MEAT. Absolute MEAT weight showed a positive correlation with IL-6 (r = 0.464), INF-alpha (r = 0.508); and adiponectin (r = 0.342). These results suggest a tissue-specific heterogeneous response in adipokines level. the combination of the protocols (aerobic training and energy restriction) did not induce an enhanced effect. Published by Elsevier B.V.en
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Canc Metab Res Grp, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Inst Heart, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Phys Educ & Sport, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 04/11588-0
dc.description.sponsorshipIDFAPESP: 05/01445-0
dc.format.extent168-174
dc.identifierhttps://dx.doi.org/10.1016/j.cyto.2010.07.006
dc.identifier.citationCytokine. London: Academic Press Ltd- Elsevier B.V., v. 52, n. 3, p. 168-174, 2010.
dc.identifier.doi10.1016/j.cyto.2010.07.006
dc.identifier.issn1043-4666
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/33123
dc.identifier.wosWOS:000284819300006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCytokine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttps://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectWhite adipose tissueen
dc.subjectEnergy restrictionen
dc.subjectAerobic trainingen
dc.subjectAdipokinesen
dc.titleDepot-specific modulation of adipokine levels in rat adipose tissue by diet-induced obesity: the effect of aerobic training and energy restrictionen
dc.typeinfo:eu-repo/semantics/article
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