OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome

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Data
2010-11-01
Autores
Bianco, Bianca Alves Vieira [UNIFESP]
Oliveira, Kelly Cristina de [UNIFESP]
Guedes, Alexis Dourado [UNIFESP]
Barbosa, Caio Parente
Lipay, Monica Vannucci Nunes [UNIFESP]
Verreschi, Ieda Therezinha do Nascimento [UNIFESP]
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To show that in the dysgenetic gonads of 104 Turner syndrome patients no significant difference was found regarding the expression of the genes DAX1, FOG2, GATA4, OCT4, SF1, SRY, TSPY, WT1, and STRA8 compared with controls, except for genes OCT4, SRY, and TSPY in both gonads of a patient whose chromosomal constitution was 45,X/45,X,add(15)(p11). the expression analysis of genes OCT4, SRY, and TSPY in the dysgenetic gonads of Turner syndrome patients may allow introducing modifications in the microenvironment that could contributed to a malignant transformation process. (Fertil Steril (R) 2010;94:2347-9. (C) 2010 by American Society for Reproductive Medicine.)
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Fertility and Sterility. New York: Elsevier B.V., v. 94, n. 6, p. 2347-2349, 2010.