Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp
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Date
2008-11-01
Authors
Brito, Adriana S.
Arimateia, Dayse S.
Souza, Lucilla R.
Lima, Marcelo A.
Santos, Vanessa O.
Medeiros, Valquiria P. [UNIFESP]
Ferreira, Paula A.
Silva, Rodrigo A.
Ferreira, Carmen V.
Justo, Giselle Z. [UNIFESP]
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Abstract
The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p < 0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug. (C) 2008 Elsevier B.V. All rights reserved.
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Bioorganic & Medicinal Chemistry. Oxford: Pergamon-Elsevier B.V., v. 16, n. 21, p. 9588-9595, 2008.