Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp

Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp

Autor Brito, Adriana S. Google Scholar
Arimateia, Dayse S. Google Scholar
Souza, Lucilla R. Google Scholar
Lima, Marcelo A. Google Scholar
Santos, Vanessa O. Google Scholar
Medeiros, Valquiria P. Autor UNIFESP Google Scholar
Ferreira, Paula A. Google Scholar
Silva, Rodrigo A. Google Scholar
Ferreira, Carmen V. Google Scholar
Justo, Giselle Z. Autor UNIFESP Google Scholar
Leite, Edda L. Google Scholar
Andrade, Giulianna P. V. Google Scholar
Oliveira, Fernanda W. Google Scholar
Nader, Helena B. Autor UNIFESP Google Scholar
Chavante, Suely F. Google Scholar
Instituição Univ Fed Rio Grande do Norte
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Resumo The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p < 0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug. (C) 2008 Elsevier B.V. All rights reserved.
Palavra-chave Glycosaminoglycans
Crustacean heparin-like compound
Anti-inflammatory activity
Heparin
Anticoagulant activity
Invertebrate
Hemorrhagic activity
Litopenaeus vannamei
Matrix metalloproteinases
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data de publicação 2008-11-01
Publicado em Bioorganic & Medicinal Chemistry. Oxford: Pergamon-Elsevier B.V., v. 16, n. 21, p. 9588-9595, 2008.
ISSN 0968-0896 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 9588-9595
Fonte http://dx.doi.org/10.1016/j.bmc.2008.09.020
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000260134400020
Endereço permanente http://repositorio.unifesp.br/handle/11600/31004

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta