Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp

Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp

Author Brito, Adriana S. Google Scholar
Arimateia, Dayse S. Google Scholar
Souza, Lucilla R. Google Scholar
Lima, Marcelo A. Google Scholar
Santos, Vanessa O. Google Scholar
Medeiros, Valquiria P. Autor UNIFESP Google Scholar
Ferreira, Paula A. Google Scholar
Silva, Rodrigo A. Google Scholar
Ferreira, Carmen V. Google Scholar
Justo, Giselle Z. Autor UNIFESP Google Scholar
Leite, Edda L. Google Scholar
Andrade, Giulianna P. V. Google Scholar
Oliveira, Fernanda W. Google Scholar
Nader, Helena B. Autor UNIFESP Google Scholar
Chavante, Suely F. Google Scholar
Institution Univ Fed Rio Grande do Norte
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Abstract The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p < 0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug. (C) 2008 Elsevier B.V. All rights reserved.
Keywords Glycosaminoglycans
Crustacean heparin-like compound
Anti-inflammatory activity
Heparin
Anticoagulant activity
Invertebrate
Hemorrhagic activity
Litopenaeus vannamei
Matrix metalloproteinases
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2008-11-01
Published in Bioorganic & Medicinal Chemistry. Oxford: Pergamon-Elsevier B.V., v. 16, n. 21, p. 9588-9595, 2008.
ISSN 0968-0896 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 9588-9595
Origin http://dx.doi.org/10.1016/j.bmc.2008.09.020
Access rights Closed access
Type Article
Web of Science ID WOS:000260134400020
URI http://repositorio.unifesp.br/handle/11600/31004

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