Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp

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dc.contributor.authorBrito, Adriana S.
dc.contributor.authorArimateia, Dayse S.
dc.contributor.authorSouza, Lucilla R.
dc.contributor.authorLima, Marcelo A.
dc.contributor.authorSantos, Vanessa O.
dc.contributor.authorMedeiros, Valquiria P. [UNIFESP]
dc.contributor.authorFerreira, Paula A.
dc.contributor.authorSilva, Rodrigo A.
dc.contributor.authorFerreira, Carmen V.
dc.contributor.authorJusto, Giselle Z. [UNIFESP]
dc.contributor.authorLeite, Edda L.
dc.contributor.authorAndrade, Giulianna P. V.
dc.contributor.authorOliveira, Fernanda W.
dc.contributor.authorNader, Helena B. [UNIFESP]
dc.contributor.authorChavante, Suely F.
dc.contributor.institutionUniv Fed Rio Grande do Norte
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2016-01-24T13:51:51Z
dc.date.available2016-01-24T13:51:51Z
dc.date.issued2008-11-01
dc.description.abstractThe anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p < 0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug. (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Rio Grande do Norte, Dept Bioquim, BR-59072970 Natal, RN, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Bioquim, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent9588-9595
dc.identifierhttp://dx.doi.org/10.1016/j.bmc.2008.09.020
dc.identifier.citationBioorganic & Medicinal Chemistry. Oxford: Pergamon-Elsevier B.V., v. 16, n. 21, p. 9588-9595, 2008.
dc.identifier.doi10.1016/j.bmc.2008.09.020
dc.identifier.issn0968-0896
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31004
dc.identifier.wosWOS:000260134400020
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBioorganic & Medicinal Chemistry
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectGlycosaminoglycansen
dc.subjectCrustacean heparin-like compounden
dc.subjectAnti-inflammatory activityen
dc.subjectHeparinen
dc.subjectAnticoagulant activityen
dc.subjectInvertebrateen
dc.subjectHemorrhagic activityen
dc.subjectLitopenaeus vannameien
dc.subjectMatrix metalloproteinasesen
dc.titleAnti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimpen
dc.typeArtigo
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