Breathing disorders in congestive heart failure: gender, etiology and mortality

Breathing disorders in congestive heart failure: gender, etiology and mortality

Author Santos-Silva, Rogerio Autor UNIFESP Google Scholar
Figueiredo, Adelaide Cristina de Google Scholar
Mady, Charles Google Scholar
Lorenzi-Filho, Geraldo Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract We investigated the relationship between sleep-disordered breathing (SDB) and Cheyne-Stokes respiration (CSR) while awake as well as mortality. Eighty-nine consecutive outpatients ( 29 females) with congestive heart failure (CHF; left ventricular ejection fraction, LVEF < 45%) were prospectively evaluated. the presence of SDB and of CSR while awake before sleep onset was investigated by polysomnography. SDB prevalence was 81 and 56%, using apnea-hypopnea index cutoffs > 5 and > 15, respectively. CHF etiologies were similar according to the prevalence of SDB and sleep pattern. Males and females were similar in age, body mass index, and LVEF. Males presented more SDB (P = 0.01), higher apnea-hypopnea index (P=0.04), more light sleep (stages 1 and 2; P < 0.05), and less deep sleep (P < 0.001) than females. During follow-up ( 25 +/- 10 months), 27% of the population died. Non-survivors had lower LVEF (P = 0.01), worse New York Heart Association (NYHA) functional classification (P=0.03), and higher CSR while awake (P < 0.001) than survivors. As determined by Cox proportional model, NYHA class IV (RR = 3.95, 95% CI = 1.37-11.38, P = 0.011) and CSR while awake with a marginal significance ( RR = 2.96, 95% CI = 0.94 - 9.33, P = 0.064) were associated with mortality. in conclusion, the prevalence of SDB and sleep pattern of patients with Chagas' disease were similar to that of patients with CHF due to other etiologies. Males presented more frequent and more severe SDB and worse sleep quality than females. the presence of CSR while awake, but not during sleep, may be associated with a poor prognosis in patients with CHF.
Keywords Sleep apnea
Cheyne-Stokes respiration
Congestive heart failure
Chagas' disease
Language English
Date 2008-03-01
Published in Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 41, n. 3, p. 215-222, 2008.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 215-222
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000253882200007
SciELO ID S0100-879X2008000300007 (statistics in SciELO)

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