Breathing disorders in congestive heart failure: gender, etiology and mortality

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dc.contributor.authorSantos-Silva, Rogerio [UNIFESP]
dc.contributor.authorFigueiredo, Adelaide Cristina de
dc.contributor.authorMady, Charles
dc.contributor.authorLorenzi-Filho, Geraldo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:36Z
dc.date.available2016-01-24T13:49:36Z
dc.date.issued2008-03-01
dc.description.abstractWe investigated the relationship between sleep-disordered breathing (SDB) and Cheyne-Stokes respiration (CSR) while awake as well as mortality. Eighty-nine consecutive outpatients ( 29 females) with congestive heart failure (CHF; left ventricular ejection fraction, LVEF < 45%) were prospectively evaluated. the presence of SDB and of CSR while awake before sleep onset was investigated by polysomnography. SDB prevalence was 81 and 56%, using apnea-hypopnea index cutoffs > 5 and > 15, respectively. CHF etiologies were similar according to the prevalence of SDB and sleep pattern. Males and females were similar in age, body mass index, and LVEF. Males presented more SDB (P = 0.01), higher apnea-hypopnea index (P=0.04), more light sleep (stages 1 and 2; P < 0.05), and less deep sleep (P < 0.001) than females. During follow-up ( 25 +/- 10 months), 27% of the population died. Non-survivors had lower LVEF (P = 0.01), worse New York Heart Association (NYHA) functional classification (P=0.03), and higher CSR while awake (P < 0.001) than survivors. As determined by Cox proportional model, NYHA class IV (RR = 3.95, 95% CI = 1.37-11.38, P = 0.011) and CSR while awake with a marginal significance ( RR = 2.96, 95% CI = 0.94 - 9.33, P = 0.064) were associated with mortality. in conclusion, the prevalence of SDB and sleep pattern of patients with Chagas' disease were similar to that of patients with CHF due to other etiologies. Males presented more frequent and more severe SDB and worse sleep quality than females. the presence of CSR while awake, but not during sleep, may be associated with a poor prognosis in patients with CHF.en
dc.description.affiliationUniv São Paulo, Fac Med, Hosp Clin,Inst Coracao, Div Pneumol,Lab Sono, BR-05403900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Hosp Clin, Inst Coracao,Unidad Insuficiencia Cardiaca, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psicobiol, Disciplina Med & Biol Sono, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psicobiol, Disciplina Med & Biol Sono, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent215-222
dc.identifierhttps://dx.doi.org/10.1590/S0100-879X2008000300007
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 41, n. 3, p. 215-222, 2008.
dc.identifier.doi10.1590/S0100-879X2008000300007
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2008000300007
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/30470
dc.identifier.wosWOS:000253882200007
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSleep apneaen
dc.subjectCheyne-Stokes respirationen
dc.subjectCongestive heart failureen
dc.subjectGenderen
dc.subjectChagas' diseaseen
dc.titleBreathing disorders in congestive heart failure: gender, etiology and mortalityen
dc.typeinfo:eu-repo/semantics/article
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