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Survivin and inducible nitric oxide synthase production during 4NQO-induced rat tongue carcinogenesis: A possible relationship

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Date
2007-08-01
Author
Ribeiro, Daniel Araki [UNIFESP]
Kitakawa, Darcio
Domingues, Maria Aparecida Custodio
Guimaraes Cabral, Luiz Antonio
Marques, Mariangela Esther Alencar
Salvadori, Daisy Maria Favero
Type
Artigo
ISSN
0014-4800
Is part of
Experimental and Molecular Pathology
DOI
10.1016/j.yexmp.2007.02.006
Metadata
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Abstract
This study was undertaken to investigate, by immunohistochermistry, the expression of survivin and inducible nitric oxide synthase during 4NQO-induced rat tongue carcinogenesis. Male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12, and 20 weeks. Ten animals were used as negative control. Although no histopathological abnormalities were induced in the epithelium after 4 weeks of carcinogen exposure, survivin and iNOS were expresssed (P < 0.05) in some cells of the 'normal' oral epithelium. in pre-neoplastic lesions at 12 weeks following carcinogen exposure, the levels of survivin and iNOS were increased (p < 0.05) when compared to negative control, being the strongest effect observed to iNOS. in well-differentiated squamous cell carcinoma induced after 20 weeks of treatment with 4NQO, survivin and iNOS were expressed in some tumor cells. Lack of immunoreactivity for both markers was observed in the negative control group. Taken together, our results support the belief that expression of survivin and iNOS are early events during malignant transformation and conversion of the oral mucosa. (c) 2007 Elsevier Inc. All rights reserved.
Citation
Experimental and Molecular Pathology. San Diego: Academic Press Inc Elsevier Science, v. 83, n. 1, p. 131-137, 2007.
Keywords
Survivin
Nitric oxide
Rat tongue mucosa
Oral squamous cell carcinoma
4-nitroquinoline 1-oxide
Malignant transformation
URI
https://repositorio.unifesp.br/handle/11600/29919
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  • ISS - Artigos [697]

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