Survivin and inducible nitric oxide synthase production during 4NQO-induced rat tongue carcinogenesis: A possible relationship

Survivin and inducible nitric oxide synthase production during 4NQO-induced rat tongue carcinogenesis: A possible relationship

Author Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Kitakawa, Darcio Google Scholar
Domingues, Maria Aparecida Custodio Google Scholar
Guimaraes Cabral, Luiz Antonio Google Scholar
Marques, Mariangela Esther Alencar Google Scholar
Salvadori, Daisy Maria Favero Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Estadual Paulista
Abstract This study was undertaken to investigate, by immunohistochermistry, the expression of survivin and inducible nitric oxide synthase during 4NQO-induced rat tongue carcinogenesis. Male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12, and 20 weeks. Ten animals were used as negative control. Although no histopathological abnormalities were induced in the epithelium after 4 weeks of carcinogen exposure, survivin and iNOS were expresssed (P < 0.05) in some cells of the 'normal' oral epithelium. in pre-neoplastic lesions at 12 weeks following carcinogen exposure, the levels of survivin and iNOS were increased (p < 0.05) when compared to negative control, being the strongest effect observed to iNOS. in well-differentiated squamous cell carcinoma induced after 20 weeks of treatment with 4NQO, survivin and iNOS were expressed in some tumor cells. Lack of immunoreactivity for both markers was observed in the negative control group. Taken together, our results support the belief that expression of survivin and iNOS are early events during malignant transformation and conversion of the oral mucosa. (c) 2007 Elsevier Inc. All rights reserved.
Keywords Survivin
Nitric oxide
Rat tongue mucosa
Oral squamous cell carcinoma
4-nitroquinoline 1-oxide
Malignant transformation
Language English
Date 2007-08-01
Published in Experimental and Molecular Pathology. San Diego: Academic Press Inc Elsevier Science, v. 83, n. 1, p. 131-137, 2007.
ISSN 0014-4800 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 131-137
Origin https://dx.doi.org/10.1016/j.yexmp.2007.02.006
Access rights Closed access
Type Article
Web of Science ID WOS:000247716800020
URI https://repositorio.unifesp.br/handle/11600/29919

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