Survivin and inducible nitric oxide synthase production during 4NQO-induced rat tongue carcinogenesis: A possible relationship

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dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.authorKitakawa, Darcio
dc.contributor.authorDomingues, Maria Aparecida Custodio
dc.contributor.authorGuimaraes Cabral, Luiz Antonio
dc.contributor.authorMarques, Mariangela Esther Alencar
dc.contributor.authorSalvadori, Daisy Maria Favero
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Estadual Paulista
dc.date.accessioned2016-01-24T13:48:56Z
dc.date.available2016-01-24T13:48:56Z
dc.date.issued2007-08-01
dc.description.abstractThis study was undertaken to investigate, by immunohistochermistry, the expression of survivin and inducible nitric oxide synthase during 4NQO-induced rat tongue carcinogenesis. Male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12, and 20 weeks. Ten animals were used as negative control. Although no histopathological abnormalities were induced in the epithelium after 4 weeks of carcinogen exposure, survivin and iNOS were expresssed (P < 0.05) in some cells of the 'normal' oral epithelium. in pre-neoplastic lesions at 12 weeks following carcinogen exposure, the levels of survivin and iNOS were increased (p < 0.05) when compared to negative control, being the strongest effect observed to iNOS. in well-differentiated squamous cell carcinoma induced after 20 weeks of treatment with 4NQO, survivin and iNOS were expressed in some tumor cells. Lack of immunoreactivity for both markers was observed in the negative control group. Taken together, our results support the belief that expression of survivin and iNOS are early events during malignant transformation and conversion of the oral mucosa. (c) 2007 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Hlth Sci, São Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Sao Jose Campos Sch Dent, Dept Oral Diagnosis, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Botucatu Med Sch, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Hlth Sci, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent131-137
dc.identifierhttps://dx.doi.org/10.1016/j.yexmp.2007.02.006
dc.identifier.citationExperimental and Molecular Pathology. San Diego: Academic Press Inc Elsevier Science, v. 83, n. 1, p. 131-137, 2007.
dc.identifier.doi10.1016/j.yexmp.2007.02.006
dc.identifier.issn0014-4800
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/29919
dc.identifier.wosWOS:000247716800020
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofExperimental and Molecular Pathology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSurvivinen
dc.subjectNitric oxideen
dc.subjectRat tongue mucosaen
dc.subjectOral squamous cell carcinomaen
dc.subject4-nitroquinoline 1-oxideen
dc.subjectMalignant transformationen
dc.titleSurvivin and inducible nitric oxide synthase production during 4NQO-induced rat tongue carcinogenesis: A possible relationshipen
dc.typeinfo:eu-repo/semantics/article
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