Effects of medial amygdala inactivation on a panic-related behavior

Effects of medial amygdala inactivation on a panic-related behavior

Author Herdade, Karina Costa Paes Google Scholar
Strauss, Christiana Villela de Andrade Google Scholar
Zangrossi Junior, Helio Google Scholar
Viana, Milena de Barros Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Pontificia Univ Catolica
Abstract In the last years, the role played by the medial nucleus of the amygdala (MeA) in the modulation of fear- and anxiety-related behaviors has been increasingly investigated. This nucleus plays an important role in the processing of predator odor-induced defensive reactions, i.e. freezing and risk-assessment behaviors. Immunohistochemical evidence also indicates that the MeA may be involved in the regulation of escape, a defensive behavior related to panic attacks. in this study, we further addressed this question by investigating the effects of the reversible inactivation of the nucleus on escape behavior generated in male Wistar rats by two different aversive stimuli, electrical stimulation of the dorsal periaqueductal gray matter (dPAG) and exposure to one of the open arms of the elevated T-maze. Results showed that intra-MeA administration of either the reversible sodium channel blocker lidocaine (34 nmol/0.2 mu l) or the GABA(A) receptor agonist muscimol (0.22 nmol/0.2 mu l) raised the threshold of aversive electrical stimulation, increasing the amount of current that applied to the dPAG evokes escape, an antiaversive effect. Local microinjection of muscimol (0.22 nmol/0.2 mu l) inhibited escape behavior in the elevated T-maze, also suggesting an antiaversive effect. in this latter test, muscimol did not affect inhibitory avoidance, a behavior associated with generalized anxiety disorder. Muscimol effect in the elevated T-maze was independent of changes in general exploratory activity as measured in an open-field. Taken together, our data corroborate previous evidences suggesting that the MeA is involved in the modulation of escape. Dysfunction of this regulatory mechanism may be of relevance in the genesis/maintenance of panic disorder. (c) 2006 Elsevier B.V. All rights reserved.
Keywords Medial amygdala
Anxiety
Fear
Escape
Generalized anxiety
Panic disorder
Language English
Date 2006-09-25
Published in Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 172, n. 2, p. 316-323, 2006.
ISSN 0166-4328 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 316-323
Origin https://dx.doi.org/10.1016/j.bbr.2006.05.021
Access rights Closed access
Type Article
Web of Science ID WOS:000240241300018
URI https://repositorio.unifesp.br/handle/11600/29159

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