Effects of medial amygdala inactivation on a panic-related behavior

dc.contributor.authorHerdade, Karina Costa Paes
dc.contributor.authorStrauss, Christiana Villela de Andrade
dc.contributor.authorZangrossi Junior, Helio
dc.contributor.authorViana, Milena de Barros [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionPontificia Univ Catolica
dc.date.accessioned2016-01-24T12:41:29Z
dc.date.available2016-01-24T12:41:29Z
dc.date.issued2006-09-25
dc.description.abstractIn the last years, the role played by the medial nucleus of the amygdala (MeA) in the modulation of fear- and anxiety-related behaviors has been increasingly investigated. This nucleus plays an important role in the processing of predator odor-induced defensive reactions, i.e. freezing and risk-assessment behaviors. Immunohistochemical evidence also indicates that the MeA may be involved in the regulation of escape, a defensive behavior related to panic attacks. in this study, we further addressed this question by investigating the effects of the reversible inactivation of the nucleus on escape behavior generated in male Wistar rats by two different aversive stimuli, electrical stimulation of the dorsal periaqueductal gray matter (dPAG) and exposure to one of the open arms of the elevated T-maze. Results showed that intra-MeA administration of either the reversible sodium channel blocker lidocaine (34 nmol/0.2 mu l) or the GABA(A) receptor agonist muscimol (0.22 nmol/0.2 mu l) raised the threshold of aversive electrical stimulation, increasing the amount of current that applied to the dPAG evokes escape, an antiaversive effect. Local microinjection of muscimol (0.22 nmol/0.2 mu l) inhibited escape behavior in the elevated T-maze, also suggesting an antiaversive effect. in this latter test, muscimol did not affect inhibitory avoidance, a behavior associated with generalized anxiety disorder. Muscimol effect in the elevated T-maze was independent of changes in general exploratory activity as measured in an open-field. Taken together, our data corroborate previous evidences suggesting that the MeA is involved in the modulation of escape. Dysfunction of this regulatory mechanism may be of relevance in the genesis/maintenance of panic disorder. (c) 2006 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ciencias Saude, BR-11060001 Santos, Brazil
dc.description.affiliationUniv São Paulo, FFCLRP, Lab Psicofarmacol, BR-14040901 Ribeirao Preto, Brazil
dc.description.affiliationUniv São Paulo, FMRP, Dept Farmacol, BR-14040901 Ribeirao Preto, Brazil
dc.description.affiliationPontificia Univ Catolica, Fac Psicol, Dept Psicol Desenvolvimento, BR-05014901 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ciencias Saude, BR-11060001 Santos, Brazil
dc.description.sourceWeb of Science
dc.format.extent316-323
dc.identifierhttps://dx.doi.org/10.1016/j.bbr.2006.05.021
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 172, n. 2, p. 316-323, 2006.
dc.identifier.doi10.1016/j.bbr.2006.05.021
dc.identifier.issn0166-4328
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/29159
dc.identifier.wosWOS:000240241300018
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectMedial amygdalaen
dc.subjectAnxietyen
dc.subjectFearen
dc.subjectEscapeen
dc.subjectGeneralized anxietyen
dc.subjectPanic disorderen
dc.titleEffects of medial amygdala inactivation on a panic-related behavioren
dc.typeArtigo
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