Sleep deprivation abolishes the locomotor stimulant effect of ethanol in mice
Data
2006-04-14
Autores
Araujo, Nilza Pereira de 
Andersen, Monica Levy
Abilio, Vanessa Costhek
Gomes, Daniele Crespo
Carvalho, Rita de Cassia
Mostrar mais
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
The present study aimed to investigate the effects of sleep deprivation (SD) on the dose-dependent stimulant effect of ethanol (ETOH) on the open-field behavior of female and male mice. Sleep-deprived (48 h, multiple platforms method) or home-cage control female mice were treated with saline (SAL) or 1.4, 1.8 or 2.2 g/kg ETOH 5 min before behavioral testing. ETOH produced a dose-dependent increase in open-field locomotor behavior. This locomotor stimulant effect did not reflect a general stimulation in motor activity, since it was accompanied by a simultaneous decrease in rearing frequency as well as by no modification in immobility duration. the effects of ETOH on these three behavioral parameters were specifically modified by SD: the locomotor stimulant effect was abolished, the rearing inhibitory effect was potentiated and the lack of effect on immobility was changed to increase in immobility. Similar results were obtained for male mice although the effects of SD had a lower magnitude. the present findings demonstrate that the acute effect of ETOH on mice's motor activity are behaviorally complex and can be specifically modulated by SD. (c) 2006 Elsevier Inc. All rights reserved.
Descrição
Citação
Brain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 69, n. 3, p. 332-337, 2006.