Sleep deprivation abolishes the locomotor stimulant effect of ethanol in mice

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dc.contributor.authorAraujo, Nilza Pereira de [UNIFESP]
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorAbilio, Vanessa Costhek [UNIFESP]
dc.contributor.authorGomes, Daniele Crespo [UNIFESP]
dc.contributor.authorCarvalho, Rita de Cassia [UNIFESP]
dc.contributor.authorSilva, Regina Helena da [UNIFESP]
dc.contributor.authorRibeiro, Rosana de Alencar [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:07Z
dc.date.available2016-01-24T12:41:07Z
dc.date.issued2006-04-14
dc.description.abstractThe present study aimed to investigate the effects of sleep deprivation (SD) on the dose-dependent stimulant effect of ethanol (ETOH) on the open-field behavior of female and male mice. Sleep-deprived (48 h, multiple platforms method) or home-cage control female mice were treated with saline (SAL) or 1.4, 1.8 or 2.2 g/kg ETOH 5 min before behavioral testing. ETOH produced a dose-dependent increase in open-field locomotor behavior. This locomotor stimulant effect did not reflect a general stimulation in motor activity, since it was accompanied by a simultaneous decrease in rearing frequency as well as by no modification in immobility duration. the effects of ETOH on these three behavioral parameters were specifically modified by SD: the locomotor stimulant effect was abolished, the rearing inhibitory effect was potentiated and the lack of effect on immobility was changed to increase in immobility. Similar results were obtained for male mice although the effects of SD had a lower magnitude. the present findings demonstrate that the acute effect of ETOH on mice's motor activity are behaviorally complex and can be specifically modulated by SD. (c) 2006 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipFundo de Auxílio ao Docente e Aluno da UNIFESP (FADA)pt
dc.description.sponsorshipAssociação Fundo de Incentivo à Psicofarmacologia (AFIP)pt
dc.format.extent332-337
dc.identifierhttps://dx.doi.org/10.1016/j.brainresbull.2006.01.006
dc.identifier.citationBrain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 69, n. 3, p. 332-337, 2006.
dc.identifier.doi10.1016/j.brainresbull.2006.01.006
dc.identifier.issn0361-9230
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/28846
dc.identifier.wosWOS:000236660900013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research Bulletin
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectOpen-fielden
dc.subjectAlcoholen
dc.subjectMotor behavioren
dc.subjectDopamineen
dc.subjectGABAen
dc.titleSleep deprivation abolishes the locomotor stimulant effect of ethanol in miceen
dc.typeinfo:eu-repo/semantics/article
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