Diets rich in polyunsaturated fatty acids: Effect on hepatic metabolism in rats

Diets rich in polyunsaturated fatty acids: Effect on hepatic metabolism in rats

Author Gaíva, Maria Helena Autor UNIFESP Google Scholar
Couto, Rosany Carvalho do Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Couto, Gilmar Eduardo Costa do Autor UNIFESP Google Scholar
Silveira, Vera Lucia Flor Autor UNIFESP Google Scholar
Ribeiro, Eliane Beraldi Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Mato Grosso Fed Univ
Abstract OBJECTIVE: We investigated the effect of diets rich in omega-6 and omega-3 fatty acids on hepatic metabolism.METHODS: Male Wistar rats, just weaned, were fed ad libitum for 8 wk with one of the following diets: rat chow (C), rat chow containing 15% (w/w) soybean oil (S). rat chow containing 15% (w/w) fish oil (F), and rat chow containing 15% soy bean and fish oil (SF 5:1. w/w). Casein was added to the fatty diets to achieve the same content of protein (20%) as the control chow. the rats were killed by decapitation, and the hepatic tissue was removed and weighed. Tissue lipid, glycogen, and protein content, in vivo lipogenesis rate, and adenosine triphosphate citrate lyase and malic enzyme activities were evaluated. Plasma total lipids, triacylglycerol, and cholesterol concentrations were assessed.RESULTS: Body weight gain was higher in F and SF than in C and S rats. Liver weight, lipid content, and lipogenesis rate increased in F and SF rats, although adenosine triphosphate citrate lyase activity decreased. Glycogen concentration decreased in S. F, and SF rats compared with C rats. Plasma total lipids and triacylglycerol concentrations were lower in F and SF than in C rats. Total and high-density lipoprotein cholesterol (HDL-C) plasma levels decreased in F rats. with maintenance of the total:HDL-C ratio. in SF rats, an increase in HDL-C led to a lower total:HDL-C ratio.CONCLUSIONS: These results indicated that an enrichment of the diet with omega-3 polyunsaturated fatty acids produces hypolipidemia but may cause changes in liver metabolism that favor lipid deposition. They also suggested that the addition of a small amount of eicosapentaenoic and docosahexacnoic polyunsaturated fatty acids to an omega-6-rich diet further improve the circulating lipid profile, in comparison with an omega-3-rich diet, but it does not prevent excess liver lipid accumulation. (C) Elsevier Science Inc. 2003.
Keywords Diet enriched with omega-3 and omega-6 fatty acids
Hepatic metabolism
Language English
Date 2003-02-01
Published in Nutrition. New York: Elsevier B.V., v. 19, n. 2, p. 144-149, 2003.
ISSN 0899-9007 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 144-149
Access rights Closed access
Type Article
Web of Science ID WOS:000180953800008

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