Diets rich in polyunsaturated fatty acids: Effect on hepatic metabolism in rats

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dc.contributor.authorGaíva, Maria Helena [UNIFESP]
dc.contributor.authorCouto, Rosany Carvalho do [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorCouto, Gilmar Eduardo Costa do [UNIFESP]
dc.contributor.authorSilveira, Vera Lucia Flor [UNIFESP]
dc.contributor.authorRibeiro, Eliane Beraldi [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionMato Grosso Fed Univ
dc.date.accessioned2016-01-24T12:33:42Z
dc.date.available2016-01-24T12:33:42Z
dc.date.issued2003-02-01
dc.description.abstractOBJECTIVE: We investigated the effect of diets rich in omega-6 and omega-3 fatty acids on hepatic metabolism.METHODS: Male Wistar rats, just weaned, were fed ad libitum for 8 wk with one of the following diets: rat chow (C), rat chow containing 15% (w/w) soybean oil (S). rat chow containing 15% (w/w) fish oil (F), and rat chow containing 15% soy bean and fish oil (SF 5:1. w/w). Casein was added to the fatty diets to achieve the same content of protein (20%) as the control chow. the rats were killed by decapitation, and the hepatic tissue was removed and weighed. Tissue lipid, glycogen, and protein content, in vivo lipogenesis rate, and adenosine triphosphate citrate lyase and malic enzyme activities were evaluated. Plasma total lipids, triacylglycerol, and cholesterol concentrations were assessed.RESULTS: Body weight gain was higher in F and SF than in C and S rats. Liver weight, lipid content, and lipogenesis rate increased in F and SF rats, although adenosine triphosphate citrate lyase activity decreased. Glycogen concentration decreased in S. F, and SF rats compared with C rats. Plasma total lipids and triacylglycerol concentrations were lower in F and SF than in C rats. Total and high-density lipoprotein cholesterol (HDL-C) plasma levels decreased in F rats. with maintenance of the total:HDL-C ratio. in SF rats, an increase in HDL-C led to a lower total:HDL-C ratio.CONCLUSIONS: These results indicated that an enrichment of the diet with omega-3 polyunsaturated fatty acids produces hypolipidemia but may cause changes in liver metabolism that favor lipid deposition. They also suggested that the addition of a small amount of eicosapentaenoic and docosahexacnoic polyunsaturated fatty acids to an omega-6-rich diet further improve the circulating lipid profile, in comparison with an omega-3-rich diet, but it does not prevent excess liver lipid accumulation. (C) Elsevier Science Inc. 2003.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, Disciplina Neurofisiol & Fisiol Endocrina, BR-04024002 São Paulo, Brazil
dc.description.affiliationMato Grosso Fed Univ, Dept Nutr & Dietet, Cuiaba, Mato Grosso, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, Disciplina Neurofisiol & Fisiol Endocrina, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent144-149
dc.identifierhttps://dx.doi.org/10.1016/S0899-9007(02)00909-7
dc.identifier.citationNutrition. New York: Elsevier B.V., v. 19, n. 2, p. 144-149, 2003.
dc.identifier.doi10.1016/S0899-9007(02)00909-7
dc.identifier.issn0899-9007
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/27136
dc.identifier.wosWOS:000180953800008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNutrition
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectDiet enriched with omega-3 and omega-6 fatty acidsen
dc.subjectNutritionen
dc.subjectHepatic metabolismen
dc.titleDiets rich in polyunsaturated fatty acids: Effect on hepatic metabolism in ratsen
dc.typeArtigo
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