PPG - Medicina (Obstetrícia)
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Navegando PPG - Medicina (Obstetrícia) por Assunto "acetylcysteine"
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- ItemAvaliação histológica da parede intestinal de ratos recém-nascidos após exposição às condições de hipóxia e reoxigenação e a modulação pela n-acetilcisteína(Universidade Federal de São Paulo (UNIFESP), 2016-12-31) Silvares, Soraia Guerra [UNIFESP]; Martins, Jose Luiz Martins [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: To evaluate the modulating effect of N-Acetylcysteine in newborn rats subjected to hypoxia and reoxygenation (H/R) in an experimental model of necrotizing enterocolitis by histological evaluation of the intestinal wall. Material and methods: We used 8 pregnant rats and their offspring of 70, divided into 5 study groups: group I: control (n = 8), group II: H /R (n = 10), group III: H/R- RN NAC (n = 21), group IV: H/R- RN/M NAC (n = 12) and group V: H /R - M NAC (n = 19). All groups except the control, were exposed to conditions of hypoxia and reoxygenation, but received NAC at different times. The animals of the H / R group were subjected to gas chamber in an atmosphere with CO2 at 100% for 10 minutes and then reoxygenated with 100% O2 for another 10 minutes 2x / day during the first three days of life. On the 3rd day of life the animals were anesthetized, laparotomy and bowel resected. Results: The H / R and NAC groups showed changes in the intestinal wall in the number of villus and in relation to the width and height villus when compared to the control group, but with better preservation of the structures in the NAC group. Conclusion: The administration of NAC decreases the damage to the intestinal wall of rats subjected to H / R.