Navegando por Palavras-chave "lupus"

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    Effect of glucan on murine lupus evolution and on host resistance to Klebsiella pneumoniae
    (Wiley-Blackwell, 1997-01-01) Harima, Helena Aiko [UNIFESP]; Mendes, Nelson Figueiredo [UNIFESP]; Mamizuka, Elsa Masae [UNIFESP]; Mariano, Mario [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    Glucan is a polysaccharide from the yeast Saccharomyces cerevisiae that stimulates the mononuclear phagocytic system (MPS). NZB/NZW F1 mice were divided into two groups: one group received a subcutaneous injection of 0.5 mg glucan/animal for 1 week, and the other received the same dose for 3 months. No changes were observed in those animals submitted to short-term glucan treatment, whereas animals with active lupus and submitted to long-term glucan administration presented early death, with significant differences in accumulated mortality rates over 33-37 weeks, when compared to controls. No deaths were observed in lupus mice treated with glucan 24 hours before the induction of septic shock by Klebsiella pneumoniae, in contrast to mortality of 95.3% in the control group during the follow-up period of 12 days. We conclude that although glucan is able to exacerbate lupus activity, it enhances resistance to infection in lupus mice. (C) 1997 Wiley-Liss, Inc.
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    Gonadal function in male adolescents and young males with juvenile onset systemic lupus erythematosus
    (J Rheumatol Publ Co, 2002-09-01) Silva, Clovis AA; Hallak, Jorge; Pasqualotto, Fabio F.; Barba, Mario F.; Saito, Maria I.; Kiss, Maria HB; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    Objective. To evaluate gonadal function in male adolescents and young men with juvenile onset systemic lupus erythematosus (SLE).Methods. Four young men with SLE underwent clinical and laboratory evaluation, testicular ultrasound, follicle stimulating hormone, luteinizing hormone, prolactin, testosterone, and and-sperm antibody determination. The semen analyses were per-formed according to the WHO guidelines and Kruger strict criteria. All patients were asked to provide 3 semen samples over a period of 2 months. A new sample was collected 6 months later.Results. The median disease duration was 6.6 years. The median age at initial ejaculation was 13.5 years. All 4 patients had severe disease with renal involvement (WHO class IV or V). The SLICC/ACR damage index at the time of study entry ranged between 0 and 3. The patients' Tanner stage was P5G5; all reported normal erection and libido. Gonadal evaluation by thorough examination of the genitalia and ultrasound was normal. Anti-sperm antibodies were negative in all patients. Only one patient showed high FSH and LH levels. The initial and final semen evaluations of the 4 patients were abnormal (azoospermia, oligoastenoteratospermia, or teratospermia). One patient was receiving azathioprine and 2 were receiving cyclophosphamide at the time of study entry.Conclusion. Although these patients had normal sexual activity and normal external genitalia, their fertility was decreased based on the sperm abnormalities. Serial semen analyses in larger study populations will be necessary to clarify the degree and duration of sperm abnormalities in male patients with SLE in general.
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    The impact of lupus erythematosus cutaneous on the quality of life: the Brazilian-Portuguese version of DLQI
    (Springer, 2006-04-01) Ferraz, L. B.; Almeida, F. A.; Vasconcellos, M. R.; Faccina, A. S.; Ciconelli, R. M.; Ferraz, M. B.; Universidade Federal de São Paulo (UNIFESP)
    Objective: To translate into Brazilian-Portuguese, culturally adapt and validate the DLQI. Patients and Methods: the DLQI was translated into Brazilian-Portuguese and cultural adaptation was performed following the methodology proposed by Falcao. Inter-observer reliability and validity were assessed. Seventy-one patients with lupus erythematosus with cutaneous lesions selected from the outpatient dermatology clinic had their quality of life assessed by DLQI and SF-36. the validity of the Brazilian-Portuguese version of the DLQI was evaluated by the correlation of DLQI scores with SF-36 component scores and other outcome measures. Results: in the translation and cultural adaptation process the basic structure of DLQI was kept. Very few questions have very slightly modifications. of the 71 patients, 83% were women and the median (SD) age was 38 (12) years. the patients had a mean (SD) disease duration of 8(6) years. There were 46 patients with active cutaneous lesions and 37 patients with alopecia. the DLQI inter-observer reliability coefficient was 0.96 (p < 0.001). the DLQI mean (SD) score was 6.5 (5.6) and most of the SF-36 domains were between 60 and 70. the domains that had the lowest scores were 'Cygeneral health' (62) and 'Cymental health' (62). the Pearson correlation coefficient between DLQI and each SF-36 component score were highly statistically significant (p < 0.001), despite of being only moderate. As expected there was no correlation between DLQI or each one of the SF-36 components and age, disease duration or number of ACR criteria. Patients with active cutaneous lesions presented statistically significant lower scores of DLQI and SF-36 when compared to patients without active cutaneous lesions. Patients with alopecia presented a statistically significant lower score in DLQI when compared to patients without alopecia. Conclusions: the results suggest that the Brazilian-Portuguese version of the DLQI is a reliable and valid outcome measure to be used in LE clinical studies.
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    Increased Disease Activity is Associated with Altered Sleep Architecture in an Experimental Model of Systemic Lupus Erythematosus
    (Amer Acad Sleep Medicine, 2010-09-01) Palma, Beatriz Duarte [UNIFESP]; Tufik, Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Study Objectives: The aim of this study was to evaluate sleep patterns during the course of the disease in (NZB/NZW)F(1) mice, an experimental model of systemic lupus erythematosus (SLE).Design: Female mice were implanted with electrodes for chronic recording of sleep-wake cycles during the entire experimental phase (9, 19, and 29 weeks of age). The disease course was also assessed. At each time-point, blood samples were collected from the orbital plexus to evaluate serum antinuclear antibodies (ANA), which are important serologic parameters of disease evolution. Pain perception was also evaluated.Measurements and Results: During the dark phase, (NZB/NZW)F(1) mice aged 19 weeks spent more time in sleep, and, as a consequence, the total waking time was lower when compared with earlier periods. An augmented number of sleep-stage transitions and microarousals were observed at the 29(th) week of life in both light and dark phases. At this same time-point, the mice showed lower pain thresholds than they had at 9 weeks of life. The disease status was confirmed; the entire group of mice at 29 weeks of life showed positive ANA with high titer levels.Conclusions: The sleep-recording data showed that, during the progress and severe phases of the disease (19 and 29 wks of age, respectively), sleep architecture is altered. According to these results, increased sleep fragmentation, disease activity, and pain sensitivity are features observed in these mice, similar to symptoms of SLE.
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    Systemic lupus erythematosus symptom checklist: Cross-cultural adaptation to Brazilian Portuguese language and reliability evaluation
    (Medfarma-edicoes Medicas, Lda, 2007-10-01) Freire, Eutilia Andrade Medeiros [UNIFESP]; Guimaraes, Eugenia; Maia, Ines; Ciconelli, Rozana Mesquita [UNIFESP]; Univ Fed Paraiba; Universidade Federal de São Paulo (UNIFESP)
    Introduction: Reliable and sensitive measurements are needed to evaluate quality of life (QOL) in patients with systemic lupus erythematosus (SLE). No lupus-specific questionnaires are available in the Portuguese language.Objectives: This study describes the translation, cultural adaptation and reliability testing of the Systemic Lupus Erythematosus Symptom Checklist questionnaire in Portuguese.Patients and Methods: We evaluated 50 patients with SLE. A protocol was developed for translating and validating the SLE Symptom Checklist, in accordance with the proposals in publications report on the methodology for translating questionnaires into foreign languages.Results: With regard to cross-cultural adaptation, some adaptations to people's culture had to be made without endangering the main objective of the questions in the original language. The correlation coefficients for internal consistency, intraobserver reproducibility and interobserver reproducibility were 0.874, 0.925 and 0.917, respectively.Conclusions: This questionnaire was shown to be reliable when applied to patients with SLE. Studies are currently being carried out to demonstrate its validity and sensitivity to changes.