Navegando por Palavras-chave "AIDS-related opportunistic infections"

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    Clinical features and outcomes of AIDS-related cytomegalovirus retinitis in the era of highly active antiretroviral therapy
    (Conselho Brasileiro de Oftalmologia, 2010-02-01) Arantes, Tiago Eugênio Faria E [UNIFESP]; Garcia, Claudio Renato [UNIFESP]; Saraceno, Janaína Jamile Ferreira [UNIFESP]; Muccioli, Cristina [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    PURPOSE: To describe the features and outcomes of patients with AIDS-related cytomegalovirus retinitis after highly active antiretroviral therapy availability. METHODS: Retrospective chart review of 30 consecutive patients (44 eyes) with AIDS and newly diagnosed, active AIDS-related cytomegalovirus retinitis, examined from January 2005 to December 2007. RESULTS: The mean age was 34.8 years, 18 patients (60.0%) were male and median duration of AIDS was 90 months. Nineteen patients (63.3%) had evidence of highly active antiretroviral therapy failure and median CD4+ lymphocyte count was 12.5 cells/µl. Visual acuity at presentation was 20/40 or better in 27 eyes (61.4%). Retinitis involved Zone 1 in 13 eyes (39.5%). Despite specific anti-AIDSrelated cytomegalovirus therapy, 16 eyes (36.4%) presented relapse of retinitis and 10 eyes (22.7%) lost at least three lines of vision. When compared to highly active antiretroviral therapy responsive patients, eyes of highly active antiretroviral therapy failure patients were more likely to develop relapse of retinitis (p=0.03) and loss of at least three lines of vision (p=0.03). CONCLUSION: The patients in this series are essentially young men with longstanding AIDS, non-responsive to highly active antiretroviral therapy and with a similar immunological profile as noted before highly active antiretroviral therapy era. These findings have implications for the management of the disease and confirm the magnitude of rational periodic screening after diagnosis of AIDS.
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    Isolated cerebellar toxoplasmosis as a complication of HIV infection
    (Royal Soc Medicine Press Ltd, 2013-01-01) Pott, H. [UNIFESP]; Castelo, A. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Isolated cerebellar mass lesion is an uncommon presentation of toxoplasmosis. the authors report one rare case in a 50-year-old HIV-infected male patient who presented with clipped speech, gait ataxia and incoordination. the cerebellar toxoplasmosis was suspected based on imaging findings, despite the atypical location. This case highlights the need for a high index of clinical suspicion among HIV-infected patients with neurological manifestations and suspicious neuroimaging findings.
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    The use of nested Polymerase Chain Reaction (nested PCR) for the early diagnosis of Histoplasma capsulatum infection in serum and whole blood of HIV-positive patients
    (Soc Brasileira Dermatologia, 2013-01-01) Dantas, Katia Cristina; Freitas, Roseli S.; Moreira, Adriana Pardini Vicentini [UNIFESP]; Silva, Marcos Vinicius da; Benard, Gil; Vasconcellos, Cidia; Criado, Paulo Ricardo; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); State Hlth Secretariat; Emilio Ribas Infectol Inst; Insitute State Publ Employees IAMSPE
    The aim of the study was to detect the rDNA sequences and their regions in Histoplasma capsulatum, which could be considered species-specific and used as a molecular method for this diagnosis by the technique of nested polymerase chain reaction (nested PCR), employing specific sequences (primers) for H. capsulatum: 18S rDNA region (HC18), 100 kDa (HC100) and the sequence 5.8 S-ITS rDNA (HC5.8). The PCR sequences HC18, HC100 and HC5.8 resulted in a specificity of 100%. The molecular assays may increase the specificity, sensitivity and speed in the diagnosis of Histoplasmosis.