PPG - Medicina (Pneumologia)

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https://hdl.handle.net/11600/61151

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Navegando PPG - Medicina (Pneumologia) por Autor "Amorim, Maria Marta Ferreira [UNIFESP]"

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    Eosinofilia do lavado nasal: um novo indicador da inflamação brônquica eosinofílica em asmáticos estáveis
    (Universidade Federal de São Paulo (UNIFESP), 2010-11-24) Amorim, Maria Marta Ferreira [UNIFESP]; Fernandes, Ana Luisa Godoy [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Background: It is noteworthy that there is a clear clinical, epidemiological and pathophysiological association between upper and lower airway inflammation in rhinitis and asthma. Objective: The aim of this study was to compare the eosinophil counts in induced sputum and nasal lavage fluids in asthma, checking their association and the accuracy of nasal eosinophilia as a predictor of sputum eosinophilia by a cross-sectional study. Methods: The clinical evaluation, asthma control questionnaire (ACQ), pre- and postbronchodilator spirometry, nasal and sputum sample was performed. The nasal eosinophilia was analysed by a receiver operating curve and logistic regression model. Results: In 140 adults, the post-bronchodilator forced expiratory volume in 1 s (FEV1) did not differ between patients with or without sputum eosinophilia (0.18). After adjusted for upper airway symptoms, age, ACQ score and post-bronchodilator FEV1, sputum eosinophilia was associated with 52 times increase in odds of nasal eosinophilia, whereas each 1% increase in bronchodilator response was associated with 7% increase in odds of nasal eosinophilia. Conclusion: This study brings further evidence that upper airway diseases are an important component of the asthma syndrome. Furthermore, monitoring of nasal eosinophilia by quantitative cytology may be useful as a surrogate of sputum cytology as a component of composite measurement for determining airway inflammation.
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    Estudo do tônus brônquico de indivíduos expostos á silica
    (Universidade Federal de São Paulo (UNIFESP), 1995) Amorim, Maria Marta Ferreira [UNIFESP]; Fernandes, Ana Luisa Godoy [UNIFESP]