New Insights on the Pathophysiology of Inspiratory Flow Limitation During Sleep

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dc.contributor.authorGodoy, Luciana B. M. de [UNIFESP]
dc.contributor.authorPalombini, Luciana O. [UNIFESP]
dc.contributor.authorMartinho Haddad, Fernanda L. [UNIFESP]
dc.contributor.authorRapoport, David M.
dc.contributor.authorVidigal, Tatiana de Aguiar [UNIFESP]
dc.contributor.authorKlichouvicz, Priscila Calixto [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorTogeiro, Sonia M. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionNYU
dc.date.accessioned2016-01-24T14:40:32Z
dc.date.available2016-01-24T14:40:32Z
dc.date.issued2015-06-01
dc.description.abstractInspiratory flow limitation (IFL) is defined as a flattened shape of inspiratory airflow contour detected by nasal cannula pressure during sleep and can indicate increased upper airway resistance especially in mild sleep-related breathing disorders (SRBD). the objective of this study was to investigate the association between upper airway abnormalities and IFL in patients with mild SRBD.This study was derived from a general population study consisting of selected individuals with apnea-hypopnea index (AHI) below 5 events/h of sleep, (no obstructive sleep apnea group) and individuals with AHI between 5 and 15 events/h (mild obstructive sleep apnea group). A total of 754 individuals were divided into four groups: group 1: AHI < 5/h and < 30 % of total sleep time (TST) with IFL (515 individuals), group 2: AHI < 5/h and > 30 % of TST with IFL (46 individuals), group 3: AHI: 5-15/h and < 30 % of TST with IFL (168 individuals), and group 4: AHI: 5-15/h and > 30 % of TST with IFL (25 individuals).Individuals with complains of oral breathing demonstrated a risk 2.7-fold larger of being group 4 compared with group 3. Abnormal nasal structure increased the chances of being in group 4 3.2-fold in comparison to group 1. Individuals with voluminous lateral wall demonstrated a risk 4.2-fold larger of being group 4 compared with group 3.More than 30 % of TST with IFL detected in sleep studies was associated with nasal and palatal anatomical abnormalities in mild SRBD patients.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, Disciplina Med & Biol Sono, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Otorrinolaringol & Cirurgia Cabeca Pescoco, BR-04024002 São Paulo, Brazil
dc.description.affiliationNYU, Sch Med, Div Pulm & Crit Care Med, New York, NY USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, Disciplina Med & Biol Sono, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Otorrinolaringol & Cirurgia Cabeca Pescoco, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent387-392
dc.identifierhttp://dx.doi.org/10.1007/s00408-015-9714-x
dc.identifier.citationLung. New York: Springer, v. 193, n. 3, p. 387-392, 2015.
dc.identifier.doi10.1007/s00408-015-9714-x
dc.identifier.issn0341-2040
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/39116
dc.identifier.wosWOS:000354475100010
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofLung
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectFlow limitationen
dc.subjectNasal cannulaen
dc.subjectSleep apneaen
dc.subjectUpper airwayen
dc.titleNew Insights on the Pathophysiology of Inspiratory Flow Limitation During Sleepen
dc.typeinfo:eu-repo/semantics/article
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