New Insights on the Pathophysiology of Inspiratory Flow Limitation During Sleep
Data
2015-06-01
Autores
Godoy, Luciana B. M. de 
Palombini, Luciana O.
Martinho Haddad, Fernanda L.
Vidigal, Tatiana de Aguiar
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Inspiratory flow limitation (IFL) is defined as a flattened shape of inspiratory airflow contour detected by nasal cannula pressure during sleep and can indicate increased upper airway resistance especially in mild sleep-related breathing disorders (SRBD). the objective of this study was to investigate the association between upper airway abnormalities and IFL in patients with mild SRBD.This study was derived from a general population study consisting of selected individuals with apnea-hypopnea index (AHI) below 5 events/h of sleep, (no obstructive sleep apnea group) and individuals with AHI between 5 and 15 events/h (mild obstructive sleep apnea group). A total of 754 individuals were divided into four groups: group 1: AHI < 5/h and < 30 % of total sleep time (TST) with IFL (515 individuals), group 2: AHI < 5/h and > 30 % of TST with IFL (46 individuals), group 3: AHI: 5-15/h and < 30 % of TST with IFL (168 individuals), and group 4: AHI: 5-15/h and > 30 % of TST with IFL (25 individuals).Individuals with complains of oral breathing demonstrated a risk 2.7-fold larger of being group 4 compared with group 3. Abnormal nasal structure increased the chances of being in group 4 3.2-fold in comparison to group 1. Individuals with voluminous lateral wall demonstrated a risk 4.2-fold larger of being group 4 compared with group 3.More than 30 % of TST with IFL detected in sleep studies was associated with nasal and palatal anatomical abnormalities in mild SRBD patients.
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Lung. New York: Springer, v. 193, n. 3, p. 387-392, 2015.