Paradoxical sleep deprivation potentiates amphetamine-induced behavioural sensitization by increasing its conditioned component
Data
2004-04-02
Autores
Frussa-Filho, Roberto 
Gonçalves, Michele Themis Moraes
Andersen, Monica Levy
Araujo, Nilza Pereira de
Chinen, Cibele Cristina
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The effects of paradoxical sleep deprivation (PSD-48 h) on the conditioned and unconditioned components of behavioural sensitization to amphetamine (two injections of 2.0 mg/kg, separated by 7 days) were studied using locomotion frequency of mice observed in an open-field as experimental parameter. Behavioural sensitization only occurred in PS deprived mice that were exposed to the open-field after the first amphetamine injection. the possible involvement of PSD in the development of a Pavlovian association between the stimulant effect of amphetamine and environmental as well as interoceptive drug cues is discussed. (C) 2004 Elsevier B.V. All rights reserved.
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Brain Research. Amsterdam: Elsevier B.V., v. 1003, n. 1-2, p. 188-193, 2004.