Resistance exercise: A non-pharmacological strategy to minimize or reverse sleep deprivation-induced muscle atrophy

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dc.contributor.authorMônico-Neto, Marcos [UNIFESP]
dc.contributor.authorAntunes, Hanna Karen Moreira [UNIFESP]
dc.contributor.authorDattilo, Murilo [UNIFESP]
dc.contributor.authorMedeiros, Alessandra [UNIFESP]
dc.contributor.authorSouza, Heitor Soares de [UNIFESP]
dc.contributor.authorLee, Kil Sun [UNIFESP]
dc.contributor.authorMelo, Camila Maria de [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCEPE
dc.date.accessioned2016-01-24T14:31:48Z
dc.date.available2016-01-24T14:31:48Z
dc.date.issued2013-06-01
dc.description.abstractSleep is important for maintenance of skeletal muscle health. Sleep debt can induce muscle atrophy by increasing glucocorticoids and decreasing testosterone, growth hormone and insulin-like growth factor-I. These hormonal alterations result in a highly proteolytic environment characterized by decreased protein synthesis and increased degradation. Given that sleep deprivation is increasingly prevalent in modern society, strategies to minimize or reverse its adverse effects need to be investigated. Resistance exercise has been suggested as an intervention that would benefit the muscle health. the practice of this type of exercise can increase the concentration of testosterone, growth hormone and insulin-like growth factor I and stimulate the protein synthesis through a key signaling molecule, mammalian target of rapamycin. Thus, we hypothesized that resistance exercise is an important non-pharmacological strategy to counteract deleterious effects of sleep debt on skeletal muscle. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationCEPE, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biociencias, Santos, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biociencias, Santos, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipCentro de Estudos em Psicobiologia e Exercicio (CEPE)
dc.description.sponsorshipCentro de Estudo Multidisciplinar em Sonolencia e Acidentes (CEMSA)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipUNIFESP
dc.description.sponsorshipFundo de Auxilio aos Docentes e Alunos (FADA)
dc.description.sponsorshipIDFAPESP: 98/14303-3
dc.description.sponsorshipIDFAPESP: 11/15962-7
dc.format.extent701-705
dc.identifierhttp://dx.doi.org/10.1016/j.mehy.2013.02.013
dc.identifier.citationMedical Hypotheses. Edinburgh: Churchill Livingstone, v. 80, n. 6, p. 701-705, 2013.
dc.identifier.doi10.1016/j.mehy.2013.02.013
dc.identifier.fileWOS000319634800004.pdf
dc.identifier.issn0306-9877
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36359
dc.identifier.wosWOS:000319634800004
dc.language.isoeng
dc.publisherChurchill Livingstone
dc.relation.ispartofMedical Hypotheses
dc.rightsAcesso aberto
dc.titleResistance exercise: A non-pharmacological strategy to minimize or reverse sleep deprivation-induced muscle atrophyen
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