Fish pollutants MeHg and Aroclor cause permanent structural damage in male gonads and kidneys after prepubertal exposure

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dc.citation.issue5
dc.citation.volume97
dc.contributor.authorGarcia, Mariana Simoes
dc.contributor.authorConstantino, Dulce Helena Jardim
dc.contributor.authorSilva, Ana Priscila Gomes [UNIFESP]
dc.contributor.authorPerobelli, Juliana Elaine [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-07-31T12:47:37Z
dc.date.available2020-07-31T12:47:37Z
dc.date.issued2016
dc.description.abstractThis study investigated whether or not prepubertal exposure to the fish contaminants methylmercury (MeHg) and the polychlorinated bisphenol Aroclor in low doses interferes with the histomorphometry of the testes, epididymis, liver and kidneys in rats. Wistar male rats, 21 days old, were allocated into the following: control (n = 17, received corn oil), MeHg (n = 17, received MeHg at 0.5 mg/kg/day), Aroclor (n = 17, received Aroclor at 1.0 mg/kg/day), low mix (n = 18, received MeHg at 0.05 mg/kg/day and Aroclor at 0.1 mg/kg/day), high mix (n = 18, received MeHg at 0.5 mg/kg/day and Aroclor at 1.0 mg/kg/day). Dosing continued from post natal day (PND) 23 to 53, by gavage. Euthanasia was performed on PND 53 or, after an interval of 62 days without exposure to chemicals, on PND 115. The degree of maturation of the seminiferous epithelium was delayed in chemical-exposed groups and testicular interstitial oedema was observed at adulthood. The pattern of male gonad organization was changed in the Aroclor group on PND 53 and in all treated groups at adulthood. The animals from Aroclor, low mix and high mix groups showed a reduction in the number of Sertoli cells. Histological evidence of renal injury was observed in all chemical-exposed groups in both ages. A probable target for MeHg and Aroclor in the reproductive system was Sertoli cells, in which possible dysfunctions could be linked to the other testicular alterations. Curiously, the main deleterious effects were late outcomes, along with the absence of synergistic interaction of MeHg and Aroclor in the parameters investigated. In conclusion, fish pollutants MeHg and Aroclor caused permanent structural damage in male gonads and kidneys after prepubertal exposure, without showing clear chemical interactions.en
dc.description.affiliationUniv Sagrado Coracao, Cent Labs Ciencia & Tecnol Ambiental, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Programa Posgrad Interdisciplinar Ciencias Saude, Campus Baixada Santista, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Ciencias Mar, Campus Baixada Santista, Sao Paulo, Brazil
dc.description.affiliationUnifespPrograma de Pós‐Gradução Interdisciplinar em Ciências da Saúde, Universidade Federal de São Paulo, Campus Baixada Santista, Santos, São Paulo, Brazil
dc.description.affiliationUnifespDepartamento de Ciências do Mar, Universidade Federal de São Paulo, Campus Baixada Santista, Santos, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2013/14477-3
dc.description.sponsorshipIDFAPESP: 2013/26797-2
dc.description.sponsorshipIDFAPESP: 2014/26283-1
dc.format.extent360-368
dc.identifierhttps://dx.doi.org/10.1111/iep.12200
dc.identifier.citationInternational Journal Of Experimental Pathology. Hoboken, v. 97, n. 5, p. 360-368, 2016.
dc.identifier.doi10.1111/iep.12200
dc.identifier.issn0959-9673
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56946
dc.identifier.wosWOS:000392018800039
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofInternational Journal Of Experimental Pathology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectChemical mixturesen
dc.subjectFish contaminantsen
dc.subjectMethylmercuryen
dc.subjectPeripubertyen
dc.subjectPolychlorinated bisphenolsen
dc.subjectRatsen
dc.titleFish pollutants MeHg and Aroclor cause permanent structural damage in male gonads and kidneys after prepubertal exposureen
dc.typeinfo:eu-repo/semantics/article
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