Pediatric dyslipidemia is associated with increased urinary ACE activity, blood pressure values, and carotidal-femoral pulse wave velocity

Página do item simplificado
dc.citation.issue46
dc.citation.volume2023
dc.contributor.authorCruz, Nayara Azinheira Nobrega [UNIFESP]
dc.contributor.authorOliveira, Lilian Caroline Gonçalves [UNIFESP]
dc.contributor.authorFernandes, Fernanda Barrinha
dc.contributor.authorZaniqueli, Divanei dos Anjos
dc.contributor.authorOliosa, Polyana Romano
dc.contributor.authorMill, José Geraldo
dc.contributor.authorCasarini, Dulce Elena [UNIFSP]
dc.contributor.authorLatteshttps://lattes.cnpq.br/8161092089656847
dc.date.accessioned2024-06-14T17:00:18Z
dc.date.available2024-06-14T17:00:18Z
dc.date.issued2023-03-24
dc.description.abstractThis study aimed to evaluate the enzymatic activity of the angiotensin-converting enzyme (ACE) in children and adolescents to investigate their relationship with dyslipidemia and other cardiometabolic alterations. Anthropometric measurements, blood pressure (BP), and fasting lipid concentrations were taken from 360 subjects. Categorization was done according to the levels of each lipoprotein (total cholesterol, triglycerides (TG), LDL-C, HDL-C, and non-HDL-C) into three groups: normolipidemic (NL), borderline (BL), and dyslipidemic (DL). Enzymatic activity in urine was measured using the substrates Z-FHL-OH and hippuryl-HL-OH (h-HL-OH) and the ACE activity ratio (Z-FHL-OH/h-HL-OH) was calculated. Dyslipidemic levels of HDL-C, TG, and LDL-C were observed in 23%, 9%, and 3% of the participants, respectively, and were more frequent in obese children (Chi-square, p < 0.001). ACE activity ratio was augmented in BL(HDL-C) when compared to NL(HDL-C) (5.06 vs. 2.39, p < 0.01), in DL(LDL-C) in comparison to BL(LDL-C) and NL(LDL-C) (8.7 vs. 1.8 vs. 3.0, p < 0.01), and in DL(non-HDL-C) than in BL(non-HDL-C) and in NL(non-HDL-C) (6.3 vs. 2.1 vs. 2.9, p = 0.02). The groups with impaired HDL-C and TG levels presented an increased diastolic BP percentile, and a higher systolic BP percentile was observed in BL(TG) and DL(TG). The carotidal-femoral pulse wave velocity (cfPWV) was higher in the groups with DL levels of TG and LDL-C than in NL groups. Hypertriglyceridemia was associated with higher cfPWV. No direct impact of the ACE activity on BP values was observed in this cohort, however, there was an association between hyperlipidemia and ACE upregulation which can trigger mechanisms driving to early onset of hypertension and cardiovascular disease. Graphical abstract exemplifying the cohort, categorization of subjects into the groups NL normolipidemic, BL borderline, DL dyslipidemic, methods, and main findings. Pediatric dyslipidemia was consistent with dyslipidemia secondary to obesity (DSO), associated with higher urinary angiotensin-converting enzyme (ACE) activity ratio, BP blood pressure values, and carotidal-femoral pulse wave velocity (cfPWV).en
dc.description.provenanceSubmitted by Nayara Azinheira Nobrega Cruz (azinheira.nayara@unifesp.br) on 2024-06-13T20:46:05Z workflow start=Step: editstep - action:claimaction No. of bitstreams: 1 Accepted_article_for_public_access.pdf: 1436250 bytes, checksum: e098e31b7311deea64f9cb7551cbfcc5 (MD5)en
dc.description.provenanceStep: editstep - action:editaction Approved for entry into archive by Mariusa Loução(mariusa.loucao@unifesp.br) on 2024-06-14T17:00:18Z (GMT)en
dc.description.provenanceMade available in DSpace on 2024-06-14T17:00:18Z (GMT). No. of bitstreams: 1 Accepted_article_for_public_access.pdf: 1436250 bytes, checksum: e098e31b7311deea64f9cb7551cbfcc5 (MD5) Previous issue date: 2023-03-24en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipID2018/16653-7
dc.description.sponsorshipID2017/17027-0
dc.format.extent1558-1569
dc.identifier.doihttps://doi.org/10.1038/s41440-023-01240-y
dc.identifier.urihttps://hdl.handle.net/11600/71206
dc.identifier.urihttps://doi.org/10.1038/s41440-023-01240-y
dc.languageeng
dc.publisherSpring Natureen
dc.relation.ispartofHypertension Researchen
dc.rightsAcesso abertoen
dc.subjectAngiotensin-converting enzymeen
dc.subjectBlood pressureen
dc.subjectCarotidal-femoral pulse wave velocityen
dc.subjectPediatric dyslipidemiaen
dc.titlePediatric dyslipidemia is associated with increased urinary ACE activity, blood pressure values, and carotidal-femoral pulse wave velocityen
dc.typeArtigo
unifesp.campusEscola Paulista de Medicina (EPM)
unifesp.departamentoMedicina
unifesp.graduateProgramMedicina Translacional
unifesp.knowledgeAreaInvestigação básica e clínica das doenças cardiovasculares
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Accepted_article_for_public_access.pdf
Tamanho:
1.37 MB
Formato:
Adobe Portable Document Format
Descrição:
This version of the article has been accepted for publication, after peer review but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41440-023-01240-y.
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
license.txt
Tamanho:
5.55 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar
Coleções
EPM - Artigos