Safflower oil: an integrated assessment of phytochemistry, antiulcerogenic activity, and rodent and environmental toxicity

Página do item simplificado
dc.contributor.authorToma, Walber
dc.contributor.authorGuimarães, Luciana Lopes
dc.contributor.authorBrito, Alba Regina Monteiro Souza
dc.contributor.authorSantos, Aldo Ramos
dc.contributor.authorCortez, Fernando Sanzi
dc.contributor.authorPusceddu, Fabio Hermes
dc.contributor.authorCesar, Augusto [UNIFESP]
dc.contributor.authorSilveira Junior, Landulfo
dc.contributor.authorPacheco, Marcos Tadeu Tavares
dc.contributor.authorPereira, Camilo Dias Seabra [UNIFESP]
dc.contributor.institutionUniversidade Santa Cecília Programa de Pós-graduação em Sustentabilidade de Ecossistemas Costeiros e Marinhos Laboratório de Pesquisa em Produtos Naturais
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Santa Cecília Laboratório de Ecotoxicologia
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Camilo Castelo Branco Instituto de Engenharia Biomédica
dc.date.accessioned2015-06-14T13:47:21Z
dc.date.available2015-06-14T13:47:21Z
dc.date.issued2014-10-01
dc.description.abstractGastric ulcers are a significant medical problem and the development of complications lead to significant mortality rates worldwide. In Brazil, Carthamus tinctorius L., Asteraceae, seeds essential oil, the safflower oil, is currently used as a thermogenic compound and as treatment for problems related to the cardiovascular system. In this study, by Raman spectroscopy, it was shown that oleic and linoleic acids are the compounds present in higher concentrations in the safflower oil. We demonstrated that safflower oil (750 mg/kg, p.o.) decrease the ulcerogenic lesions in mice after the administration of hydrochloric acid-ethanol. The gastric ulcers induced by non-steroidal anti-inflammatory drug (NSAID) in mice treated with cholinomimetics were treated with four different doses of safflower oil, of which, the dose of 187.5 mg/kg (p.o.) showed significant antiulcerogenic properties (**p < 0.01). Moreover, the safflower oil at doses of 187.5 mg/kg (i.d.) increased the pH levels, gastric volume (**p < 0.01) and gastric mucus production (***p < 0.001), and decreased the total gastric acid secretion (***p < 0.001). The acute toxicity tests showed that safflower oil (5.000 mg/kg, p.o.) had no effect on mortality or any other physiological parameter. Ecotoxicological tests performed using Daphnia similis showed an EC50 at 223.17 mg/l, and therefore safflower oil can be considered “non-toxic” based on the directive 93/67/EEC on risk assessment for new notified substances by European legislation. These results indicate that the antiulcer activity of Safflower oil may be due to cytoprotective effects, which serve as support for new scientific studies related to this pathology.en
dc.description.affiliationUniversidade Santa Cecília Programa de Pós-graduação em Sustentabilidade de Ecossistemas Costeiros e Marinhos Laboratório de Pesquisa em Produtos Naturais
dc.description.affiliationUniversidade Estadual de Campinas Departamento de Fisiologia e Biofísica Laboratório de Produtos Naturais
dc.description.affiliationUniversidade Santa Cecília Laboratório de Ecotoxicologia
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Instituto do Mar
dc.description.affiliationUniversidade Camilo Castelo Branco Instituto de Engenharia Biomédica
dc.description.affiliationUnifespUNIFESP, Instituto do Mar
dc.description.sourceSciELO
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2009/01788-5
dc.format.extent538-544
dc.identifierhttps://dx.doi.org/10.1016/j.bjp.2014.09.004
dc.identifier.citationRevista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 24, n. 5, p. 538-544, 2014.
dc.identifier.doi10.1016/j.bjp.2014.09.004
dc.identifier.fileS0102-695X2014000500538.pdf
dc.identifier.issn0102-695X
dc.identifier.scieloS0102-695X2014000500538
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/8644
dc.identifier.wosWOS:000346075000006
dc.language.isoeng
dc.publisherSociedade Brasileira de Farmacognosia
dc.relation.ispartofRevista Brasileira de Farmacognosia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntiulcerogenic activityen
dc.subjectEcotoxicologyen
dc.subjectRaman spectroscopyen
dc.subjectSafflower oilen
dc.subjectToxicologyen
dc.titleSafflower oil: an integrated assessment of phytochemistry, antiulcerogenic activity, and rodent and environmental toxicityen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S0102-695X2014000500538.pdf
Tamanho:
891.64 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
IMar - Artigos